1,468 results found
    1. Evolutionary Biology

    Modeling the spatiotemporal spread of beneficial alleles using ancient genomes

    Rasa A Muktupavela, Martin Petr ... Fernando Racimo
    A new method for inferring the spatiotemporal dynamics governing the spread of an advantageous mutation using ancient DNA.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Solute exchange through gap junctions lessens the adverse effects of inactivating mutations in metabolite-handling genes

    Stefania Monterisi, Johanna Michl ... Pawel Swietach
    Imaging studies of connexin-coupled networks of colorectal cancer cells reveal that cells carrying a genetic defect in an essential metabolic pathway can be rescued by diffusive exchange with neighboring wild-type cells via gap junctions, particularly Cx26, thereby evading negative selection.
    1. Neuroscience

    Inference of nonlinear receptive field subunits with spike-triggered clustering

    Nishal P Shah, Nora Brackbill ... EJ Chichilnisky
    Nonlinear receptive field subunits in retinal ganglion cells are isolated and characterized by clustering spike-triggered stimuli, and validated on population responses to naturalistic and novel closed loop stimuli.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics

    Jeremiah Keyes, Ambhighainath Ganesan ... Jin Zhang
    An individual extracellular signal regulates multiple cellular actions through differences in the temporal dynamics of spatially distinct populations of the central signaling enzyme, extracellular-signal regulated kinase.
    1. Computational and Systems Biology
    2. Neuroscience

    Statistical context dictates the relationship between feedback-related EEG signals and learning

    Matthew R Nassar, Rasmus Bruckner, Michael J Frank
    The P300, an electroencephalography (EEG) component known to be evoked by surprising events, predicts learning in a bidirectional manner that depends critically on the surrounding statistical context.
    1. Neuroscience

    Spatiotemporal organisation of human sensorimotor beta burst activity

    Catharina Zich, Andrew J Quinn ... Sven Bestmann
    Burst activity can be described in all three signal domains and sensorimotor beta burst activity propagates along two axes either parallel or perpendicular to the central sulcus.
    1. Developmental Biology
    2. Neuroscience

    Synaptic and intrinsic mechanisms underlying development of cortical direction selectivity

    Arani Roy, Jason J Osik ... Stephen D Van Hooser
    The development of neural responses proceeds through both the expansion and contraction of receptive field structure, and in addition depends upon changes in excitability of individual cells.
    1. Ecology

    Human disturbance increases spatiotemporal associations among mountain forest terrestrial mammal species

    Xueyou Li, William V Bleisch ... Xue-Long Jiang
    Human disturbance can push mammals together into more frequent encounters and associations.
    1. Neuroscience

    Neural representation of abstract task structure during generalization

    Avinash R Vaidya, Henry M Jones ... David Badre
    The human brain maintains a representation of latent task states within frontoparietal networks during the generalization of behaviors to novel settings.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Philosophy of Biology: The meanings of 'function' in biology and the problematic case of de novo gene emergence

    Diane Marie Keeling, Patricia Garza ... Anne-Ruxandra Carvunis
    A lexicon to help scientists and philosophers discuss the meaning of function in molecular biology more clearly is proposed.

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