Browse our latest Cancer Biology articles

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    1. Cancer Biology
    2. Computational and Systems Biology

    Predicting progression-free survival after systemic therapy in advanced head and neck cancer: Bayesian regression and model development

    Paul R Barber, Rami Mustapha ... Tony Ng
    Circulating immune cells reflect intra-tumoural immunity and can predict response to systemic therapy in head and neck cancer.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction

    Jacob M Winter, Heidi L Fresenius ... Jared Rutter
    A common genomic deletion in various human cancers disrupts mitochondrial protein homeostasis in a way that might be targeted by existing drugs.
    1. Cancer Biology
    2. Evolutionary Biology

    Parallel evolution of reduced cancer risk and tumor suppressor duplications in Xenarthra

    Juan Manuel Vazquez, Maria T Pena ... Vincent J Lynch
    Sloths, armadillos, and anteaters evolved genetic and cellular traits that make them remarkably cancer resistant.
    1. Cancer Biology
    2. Immunology and Inflammation

    VLA-4 suppression by senescence signals regulates meningeal immunity and leptomeningeal metastasis

    Jiaqian Li, Di Huang ... Ying Wang
    Senescence signals in tumor-specific cytotoxic T lymphocytes inhibit their trafficking from deep cervical lymph nodes to meninges via downregulating VLA-4, leading to leptomeningeal metastasis.
    1. Cancer Biology
    2. Medicine

    Procalcitonin for antimicrobial stewardship among cancer patients admitted with COVID-19

    Hiba Dagher, Anne-Marie Chaftari ... Issam Raad
    Procalcitonin could be useful in enhancing antimicrobial stewardship in cancer patients with COVID-19.
    1. Cancer Biology
    2. Genetics and Genomics

    Gallbladder adenocarcinomas undergo subclonal diversification and selection from precancerous lesions to metastatic tumors

    Minsu Kang, Hee Young Na ... Jong Seok Lee
    As the first to track clonal evolution from precancerous to metastatic lesions in gallbladder cancer patients, spatial and temporal analyses reveal how subclonal diversity in precancerous stage changes toward the metastasis, which help early detection and effective treatment of cancer.
    1. Cancer Biology

    Weakly migratory metastatic breast cancer cells activate fibroblasts via microvesicle-Tg2 to facilitate dissemination and metastasis

    Samantha C Schwager, Katherine M Young ... Cynthia A Reinhart-King
    Weakly migratory cancer cells facilitate their own escape from the primary tumor by releasing microvesicles that activate fibroblasts to remodel matrix and facilitate cancer cell metastasis.
    1. Cancer Biology

    Shifting the focus of zebrafish toward a model of the tumor microenvironment

    Joshua M Weiss, Dianne Lumaquin-Yin ... Richard M White
    Zebrafish provide unique resources for the study of the tumor microenvironment.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Clonal transcriptomics identifies mechanisms of chemoresistance and empowers rational design of combination therapies

    Sophia A Wild, Ian G Cannell ... Kirsty Sawicka
    Lineage resolved single-cell RNA-seq of mammary carcinoma models uncovers a metabolic vulnerability of taxane-resistant clones.
    1. Cancer Biology
    2. Computational and Systems Biology

    Defining cellular population dynamics at single-cell resolution during prostate cancer progression

    Alexandre A Germanos, Sonali Arora ... Andrew C Hsieh
    A large-scale single-cell RNA sequencing experiment explores single-cell dynamics in epithelial and immune populations within murine prostates upon cancer initiation and progression and validates key findings across orthogonal models and patient specimens.