Ilaria Dutto, Julian Gerhards ... Travis H Stracker
Analysis of adenylosuccinate lyase (ADSL) deficiency in multiple experimental systems reveals cell and organismal phenotypes and impaired neurodevelopment due to the attenuation of ADSL's roles in distinct pathways.
Genetically modified mouse model and comprehensive analysis reveal the molecular mechanisms regulating early T-cell development through intracellular TCRβ expression-mediated β-selection and independent cell survival signaling.
Veronika Miskolci, Kelsey E Tweed ... Anna Huttenlocher
Lifetime imaging of endogenous metabolic coenzymes is sensitive to dynamic changes in macrophage activation in a live animal, providing a label-free imaging approach to study immunometabolism in vivo with single-cell, spatial, and temporal resolution.
Vibha Kumra Ahnlide, Johannes Kumra Ahnlide ... Pontus Nordenfelt
A method to carefully measure the molecular distance between a site of interest and a reference surface by the repeated acquisition of the two image channels followed by the statistical calculation of the relative difference.
Wouter Huiting, Suzanne L Dekker ... Steven Bergink
Various genotoxic stresses trigger widespread aggregation of abundant, liquid-liquid phase separation-prone proteins, suggesting that genotoxic stress is a potential driver of disease-associated protein aggregation.
Nuclei of the true slime mold Physarum polycephalum are continuously shuttled within the cytoplasmic flow across the gigantic syncytium, yet Physarum can establish and maintain gene expression heterogeneity between different structures of the organism.
Heparan sulfate-RAGE interaction is essential for normal function of RAGE in osteoclastogenesis and drug-induced liver damage, which can be targeted to curb RAGE activation as a new opportunity.
Oxidative stress following a lung injury can alter the structure of collagen, causing it to stiffen and trigger the formation of a fibrotic scar that further hardens the tissue.
