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Identification of a heparan sulfate proteoglycan with a dedicated function in unconventional protein secretion reveals an intimate relationship between fibroblast growth factor 2 and Glypican-1 in cancer biology.

Actin-related protein 5 antagonizes the interaction of Pbx/Meis with myogenic regulatory factors such as MyoD and MyoG, which is involved in the recruitment of the BRG1-based switch/sucrose nonfermentable chromatin remodeling complex required for myogenic gene activation.

Dynamic interactions of core clock molecules are quantitively measured and mathematically modelled to reveal the hidden role of PER:CRY complexes in enhancing the mobility of CLOCK:BMAL1 to move to new DNA sites.

Centriole rotational asymmetry, a structural property necessary for cytoskeletal organization in unicellular eukaryotes, is broadly conserved in the centrioles of human cells.

Based on 3D visualization of fluorescently labeled cytoskeletal networks, an imaging platform is provided, which allows 3D network reconstruction, immersive visualization and quantification of local network properties serving as blueprints for functional modeling.

Mapping intermediate filaments in three dimensions reveals that the organization of these filaments differs across cell types.

A novel co-translational mechanism continuously adjusts the expression levels of ribosomal proteins Rpl3 and Rpl4 to their consumption during ribosome synthesis by regulating the abundance of their mRNAs.

Hyperphosphatemia, by itself and in the context of chronic kidney disease, contributes to iron restrictive anemia by directly targeting the liver and elevating proinflammatory cytokines and hepcidin, which contributes to widespread tissue injury, such as skeletal muscle wasting.

Activation of adiponectin receptors in young and aged mice induces changes in muscular metabolism via stimulation of AMPK and PGC-1a and ameliorates age-related muscle loss of function.

Rapid depletion of dynein from oocytes yielded new insights into acentrosomal pole organization and also led to the first evidence that the kinesin-5 motor BMK-1 plays a role in microtubule organization during C. elegans meiosis.