Browse our latest Cell Biology articles

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    1. Cell Biology

    CXCR4high megakaryocytes regulate host-defense immunity against bacterial pathogens

    Jin Wang, Jiayi Xie ... Meng Zhao
    scRNA-seq identified CXCR4high MKs can funtionally regulate host-defense immune response against bacterial infection.
    1. Cell Biology

    Ubiquitination drives COPI priming and Golgi SNARE localization

    Swapneeta S Date, Peng Xu ... Todd R Graham
    The ability of COPI to bind polyubiquitin is a key determinant for SNARE incorporation into intracellular vesicles and for maintenance of a functional Golgi complex.
    1. Cell Biology

    Distinct roles for two Caenorhabditis elegans acid-sensing ion channels in an ultradian clock

    Eva Kaulich, Trae Carroll ... Denise S Walker
    Two acid-sensing members of the degenerin/epithelial sodium channel family play distinct roles in controlling different aspects of rhythmic proton and calcium oscillations in the nematode intestine.
    1. Cell Biology

    Modular, cascade-like transcriptional program of regeneration in Stentor

    Pranidhi Sood, Athena Lin ... Wallace F Marshall
    Regeneration of single Stentor coeruleus cells is accompanied by a program of gene expression that can be decomposed into distinct modules, showing a cascade-like organization, and involving genes with conserved function in development and cell cycle control.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Full spectrum flow cytometry reveals mesenchymal heterogeneity in first trimester placentae and phenotypic convergence in culture, providing insight into the origins of placental mesenchymal stromal cells

    Anna Leabourn Boss, Tanvi Damani ... Anna ES Brooks
    Full spectrum flow cytometry reveals a high degree of placental mesenchymal cell heterogeneity, which is lost with culture, highlighting the importance of detailed ex vivo phenotyping to optimise the use of these cells in downstream applications.
    1. Cell Biology
    2. Physics of Living Systems

    Three-dimensional structure of kinetochore-fibers in human mitotic spindles

    Robert Kiewisz, Gunar Fabig ... Thomas Müller-Reichert
    Comprehensive 3D electron tomography reconstructions of metaphase spindles in human tissue culture cells reveal that kinetochore-fibers broaden as they extend polewards, forming semi-direct connections to the pole, where they preferentially interact with the spindle network.
    1. Cell Biology

    Isoform-specific mutation in Dystonin-b gene causes late-onset protein aggregate myopathy and cardiomyopathy

    Nozomu Yoshioka, Masayuki Kurose ... Hirohide Takebayashi
    Dystonin-b-specific mutant mice exhibit late-onset myopathy and cardiomyopathy.
    1. Cell Biology
    2. Neuroscience

    Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia

    Lauritz Kennedy, Emilie R Glesaaen ... Johanne E Rinholm
    HCAR1 knockout mice are unable to initiate brain tissue repair after a hypoxic-ischemic injury.
    1. Cell Biology
    2. Developmental Biology

    Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina

    Swathy Babu, Yuki Takeuchi, Ichiro Masai
    Banp is a transcription activator of cell cycle genes like cenpt, ncapg, and wrnip1 to prevent genotoxic stress during rapid cell division and its repercussions on development and disease.
    1. Cell Biology

    Septin7 is indispensable for proper skeletal muscle architecture and function

    Mónika Gönczi, Zsolt Ráduly ... László Csernoch
    Septin7 is described as a novel component of skeletal muscle cytoskeleton with essential roles in muscle development and the proper organization of the myofilaments and the mitochondrial network while its absence leeds to reduced force and skeletal deformities.