Quantitative proof that persistent cell migration in the timescale of hours relies on a feedback between polarized trafficking and protrusive activity stabilizing cell front.
Elvira Forte, Mirana Ramialison ... Milena B Furtado
Adult mouse fibroblasts maintain an embryonic gene expression signature, inherited from their organ of origin, that is important for organ homeostasis and fibrosis, and may assist in targeting fibrotic diseases in an organ-specific manner.
Macrophages use integrin-dependent 3D movement and cell protrusiveness, which control cell motility and space exploration as a prerequisite for optimal clearance of particles and dead cells by macrophage networks.
The general transcription factor TFIIH complex promotes the establishment and maintenance of chromosome structure during mitosis by altering the chromatin environment to allow for proper loading and function of the condensin complexes on chromatin.
Modulation of dermal adipocytes contributes to skin homeostasis and provides a promising new therapeutic strategy in the treatment of EGFRI-related skin disorders.
TIGAR deficiency in cholinergic neuron enhanced intracellular acetyl-CoA levels and pyruvate dehydrogenase flux into the TCA cycle that drives increased cholinergic tone with reduced heart rate and blood pressure and raised resistance against the paralytic curare and cold-induced hypothermia.
Electrical and biomechanical stimuli directly bias cortical signal transduction and cytoskeletal waves, and the direct bias induced by an electric field develops slowly compared to the rapid surface-receptor-mediated response to chemotactic gradients.
Chiara Piantoni, Manuel Paina ... Mirko Baruscotti
A Traditional Chinese Medicine botanical drug exerts a competitive antagonism on the cAMP-induced modulation of sinoatrial node pacemaker channels and this functional inhibition reduces the slope of the diastolic depolarization hence spontaneous cell automaticity.
