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CapZ controls actin filament density around immature early endosomes via its C-terminal domain to facilitate the homotypic fusion of the endocytic vesicles, and it functions as a scaffold protein via its N-terminal domain to recruit RAB5 effectors to early endosomes.

Unidirectional crosstalk occurs between signaling competent EGFR dimers activating RON within heteromeric complexes at the plasma membrane.

A novel process by which counter-regulatory glucagon release is regulated in both mouse and human.

Cholesterol accessibility in the plasma membrane can be controlled by proteins and function as a signaling messenger in cell-cell communication pathways.

The family of ANTH domain proteins serve as adaptors to endocytose ubiquitinated proteins from the cell surface.

Type 1 polyisoprenoid diphosphate phosphatase (PDP1) contributes to interconversion of isoprenols and isoprenylpyrophosphates, balancing the sterol and nonsterol branches of the mevalonate pathway by regulating ERAD of HMG CoA reductase and ER-to-Golgi transport of UBIAD1.

Cationic cell-penetrating peptides (CPPs) enter cells through ~2 (–5)-nm-wide water pores induced by the strong negative plasma membrane potential that CPPs and the activity of potassium channels generate.

Oon and Prehoda discover cortical actomyosin dynamics that polarize asymmetrically dividing neural stem cells.

The IRE1/XBP1 signaling in myofibers is essential for robust skeletal muscle regeneration in response to injury.

Through interactions with both ubiquitin units that emanate from a branch point in polyubiquitin, UCH37 recognizes and hydrolyzes branched chains to promote proteasome-mediated degradation upon proteolytic stresses.