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The Drosophila PNG kinase controls mRNA translation at the oocyte-to-embryo transition, and its GNU activating subunit is shown here to bind translational repressors and be a component of RNP granules.

Cell imaging and electrophysiology in the mouse hippocampus reveal a crucial role for the spatiotemporal regulation of mitochondrial dynamics in PV+ interneurons on cell morphology, network activity, and behavior.

An unbiased proteomic approach identifies a new regulator of AMPA receptor trafficking providing additional insight into synaptic transmission and plasticity.

An anchored phosphatase-deacetylase complex participates in primary cilia development.

The serine protease Matriptase orchestrates simultaneous epithelial cell motility and inflammation in pathological states through respective activation of the MAPK pathway and generation of hydrogen peroxide.

Non-canonical ‘testis-specific’ actin-related protein (Arp), Arp53D, is critical for early embryonic development in Drosophila, revealing important roles for lineage-specific, divergent, testis-expressed non-canonical Arps outside the male germline in animals.

Synchronized β cell response to glucose is lost concomitant with loss of islet architecture in Robo-deficient islets of Langerhans in vivo.

The solubility product, a thermodynamic concept classically applied to poorly soluble ionic solutes, can rationalize the concentration dependence for liquid-liquid phase separation of multicomponent multivalent molecules.

Proteomic and genetic analysis discovers a new cytoskeletal mechanism of presynaptic short-term plasticity common across neuronal cell types.

Extended biochemical and functional analyses in primary neurons show that early neuronal morphogenesis critically relies on cooperation of the actin nucleator Cobl and its ancestor Cobl-like and uncover their cooperative mechanisms at dendritic branch initiation sites.