James F Pelletier, Christine M Field ... Timothy J Mitchison
Live imaging of multiple cytoplasmic networks in frog egg extracts calls for new models for how egg cytoplasm is physically organized during cleavage divisions.
Kathleen M Cunningham, Kirstin Maulding ... Thomas E Lloyd
Impaired nuclear import of the transcription factor TFEB/MITF is a major cause of autophagy and lysosome dysfunction in amyotrophic lateral sclerosis caused by mutations in the C9orf72 gene.
Dana M Talsness, Katie G Owings ... Clement Y Chow
An ion transporter is hyperglycosylated and 50% less functional in NGLY1-deficient cells, potentially explaining several symptoms of NGLY1 deficiency such as lack of sweat and tears.
Victoria G Castiglioni, Helena R Pires ... Mike Boxem
PAR-6 and PKC-3/aPKC are essential for postembryonic development of C. elegans and control the organization of non-centrosomal microtubule bundles in the epidermis, likely through recruitment of NOCA-1/Ninein.
Class 1 histone deacetylase (HDAC) inhibitor MS-275 enhances the efficacy of glucagon-like peptide 1 receptor (GLP-1R) therapy for glycemic control and reduction of obesity.