Quantitative analyses of yeast P bodies reveals a small number of highly concentrated proteins and many weakly concentrated proteins, suggesting that the compartments are compositionally simpler than previously thought.
Efficient nuclear transport of very large biomolecules, relevant for viral transport, scales non-linearly with size and its kinetics can be explained by a simple two-parameter energetic model.
Ashna Alladin, Lucas Chaible ... Martin Jechlinger
The presented primary epithelial acinus-based platform for studying interactions between normal and malignant cells will enable in depth analysis of the tumor initiation process on a molecular level.
Steven M Markus, Matthew G Marzo, Richard J McKenney
The role of LIS1 in dynein-mediated transport in various biological contexts is reviewed with a focus on recent studies that revealed a new mechanism by which LIS1 functions.
Grace E Hamilton, Luke A Helgeson ... Trisha N Davis
Two components of the inner kinetochore (OA and Mif2) are independently capable of transmitting physiologically relevant forces to a centromeric nucleosome.
CD56/NCAM, the prototypical marker of human natural killer cells, promotes lytic function towards susceptible target cells by signaling through protein tyrosine kinase 2 (Pyk2).