Browse our latest Cell Biology articles

Page 186 of 315
    1. Cell Biology
    2. Computational and Systems Biology

    Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan

    Simeon Leupold, Georg Hubmann ... Matthias Heinemann
    With replicative age, S. cerevisiae shifts from a fermentative towards an unusual respiratory metabolism, accompanied by a decrease in growth and glucose uptake rate.
    1. Cell Biology

    An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

    David J Thaller, Matteo Allegretti ... C Patrick Lusk
    ESCRT-driven mechanisms that sense and seal holes in the nuclear membranes directly monitor the nuclear transport system and the exposure of the inner nuclear membrane.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi, Ralph Patrick ... Richard P Harvey
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Cell Biology
    2. Genetics and Genomics

    Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity

    Nicolas J Lehrbach, Gary Ruvkun
    SKN-1A/Nrf1 promotes healthy aging by activating protein degradation in response to accumulation of misfolded proteins.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Proteotoxicity from aberrant ribosome biogenesis compromises cell fitness

    Blake W Tye, Nicoletta Commins ... L Stirling Churchman
    Rapidly proliferating cells are at risk of compromised cell fitness due to proteostasis collapse from perturbations that interfere with ribosome biogenesis.
    1. Cell Biology

    Luciferase-LOV BRET enables versatile and specific transcriptional readout of cellular protein-protein interactions

    Christina K Kim, Kelvin F Cho ... Alice Y Ting
    SPARK2 allows a transcriptional readout of inter- and intracellular protein-protein interactions, with near-zero background, by employing proximity-dependent luciferase-LOV regulation.
    1. Cell Biology

    The homophilic receptor PTPRK selectively dephosphorylates multiple junctional regulators to promote cell–cell adhesion

    Gareth W Fearnley, Katherine A Young ... Hayley J Sharpe
    Systematic proteomic approaches identify several cell junction regulators as substrates for the homophilic receptor tyrosine phosphatase PTPRK and implicate its pseudophosphatase domain in substrate recognition.
    1. Cell Biology
    2. Developmental Biology

    Patronin governs minus-end-out orientation of dendritic microtubules to promote dendrite pruning in Drosophila

    Yan Wang, Menglong Rui ... Fengwei Yu
    A minus-end-binding stabilizes minus-end-out microtubules in dendrites, which are required for dendrite-specific pruning during neuronal remodelling.
    1. Cell Biology

    Philosophy of Biology: Drawing and the dynamic nature of living systems

    Gemma Anderson, John Dupré, James G Wakefield
    Drawing may be a way to better understand a biological process and to explore and develop scientific ideas.
    1. Cell Biology
    2. Plant Biology

    Kinetochore protein depletion underlies cytokinesis failure and somatic polyploidization in the moss Physcomitrella patens

    Elena Kozgunova, Momoko Nishina, Gohta Goshima
    Lagging chromosomes in anaphase inhibits cytokinesis in plant cells.