Browse our latest Cell Biology articles

Page 186 of 327
    1. Cell Biology

    Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

    Kie Itoh, Daisuke Murata ... Hiromi Sesaki
    Genetic and cell biological analyses reveal a new role of Drp1 in postsynaptic endocytosis during brain development beyond mitochondrial division GTPase.
    1. Cell Biology

    Native adiponectin in serum binds to mammalian cells expressing T-cadherin, but not AdipoRs or calreticulin

    Shunbun Kita, Shiro Fukuda ... Iichiro Shimomura
    Binding study of native adiponectin existing in serum supported the importance of T-cadherin but not AdipoRs nor calreticulin.
    1. Cell Biology
    2. Immunology and Inflammation

    Transient protein accumulation at the center of the T cell antigen-presenting cell interface drives efficient IL-2 secretion

    Danielle J Clark, Laura E McMillan ... Christoph Wülfing
    A membrane-associated, supramolecular protein complex with dynamically changing components, the central supramolecular activation cluster, regulates the generation of the T cell effector cytokine IL-2 depending on its composition.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The lysosomal transporter MFSD1 is essential for liver homeostasis and critically depends on its accessory subunit GLMP

    David Massa López, Melanie Thelen ... Markus Damme
    The so far uncharacterized lysosomal transporter protein MFSD1 is essential for liver homeostasis and needs the highly glycosylated GLMP protein as an accessory subunit for stability.
    1. Cell Biology

    β-blockers augment L-type Ca2+ channel activity by targeting spatially restricted β2AR signaling in neurons

    Ao Shen, Dana Chen ... Yang K Xiang
    FRET biosensor-based measurement of cAMP signaling and single-channel recording reveal that β-blockers trigger local activation of adrenergic receptors and calcium channels in primary neurons.
    1. Cell Biology
    2. Developmental Biology

    Mitochondrial fusion is required for spermatogonial differentiation and meiosis

    Grigor Varuzhanyan, Rebecca Rojansky ... David C Chan
    Mitochondrial fusion enables a metabolic transition during spermatogenesis.
    1. Cell Biology

    Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress

    Abigail Buchwalter, Roberta Schulte ... Martin Hetzer
    Emerin, a protein that plays key roles in nuclear organization, can be dynamically degraded in response to environmental stimuli such as ER stress.
    1. Cell Biology

    TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium

    Karen Baker, Irene A Gyamfi ... Daniel P Mulvihill
    IQ domain phosphorylation regulates calmodulin binding and myosin-1 function.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

    Xiaocheng Zhao, Pavel Nedvetsky ... Holger Gerhardt
    The cAMP-dependent protein kinase A controls the switch from actively sprouting new blood vessel formation to vessel quiescence by reducing endothelial autophagy through phosphorylation-mediated destabilisation of ATG16L1.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    H3K9me2 orchestrates inheritance of spatial positioning of peripheral heterochromatin through mitosis

    Andrey Poleshko, Cheryl L Smith ... Jonathan A Epstein
    The histone modification H3K9me2 marks peripheral heterochromatin and ensures positional information is safeguarded through cell division such that individual lamina-associated domains are re-established at the nuclear periphery in daughter nuclei.