Simeon Leupold, Georg Hubmann ... Matthias Heinemann
With replicative age, S. cerevisiae shifts from a fermentative towards an unusual respiratory metabolism, accompanied by a decrease in growth and glucose uptake rate.
David J Thaller, Matteo Allegretti ... C Patrick Lusk
ESCRT-driven mechanisms that sense and seal holes in the nuclear membranes directly monitor the nuclear transport system and the exposure of the inner nuclear membrane.
Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
Blake W Tye, Nicoletta Commins ... L Stirling Churchman
Rapidly proliferating cells are at risk of compromised cell fitness due to proteostasis collapse from perturbations that interfere with ribosome biogenesis.
SPARK2 allows a transcriptional readout of inter- and intracellular protein-protein interactions, with near-zero background, by employing proximity-dependent luciferase-LOV regulation.
Gareth W Fearnley, Katherine A Young ... Hayley J Sharpe
Systematic proteomic approaches identify several cell junction regulators as substrates for the homophilic receptor tyrosine phosphatase PTPRK and implicate its pseudophosphatase domain in substrate recognition.