Herschel S Dhekne, Izumi Yanatori ... Suzanne R Pfeffer
Pathogenic LRRK2kinase requires Rab10 and RILPL1 to block primary cilia formation, shortening cilia on cholinergic neurons needed for a hedgehog driven circuit that supports dopaminergic neurons in mouse brain.
Lars-Eric Fielmich, Ruben Schmidt ... Sander van den Heuvel
New germline gene expression, knockout, and optogenetic tools reveal essential roles for Gα-GPR-1,2/Pins as a regulatable membrane anchor and LIN-5/NuMA as an activator of cortical dynein in mitotic spindle positioning.
Laura Vuolo, Nicola L Stevenson ... David J Stephens
Genetic knock-outs of the dynein-2 intermediate chains reveals that both are essential for correct cilia function and transition zone organization, but play different functions in the assembly of dynein-2 motor and in primary cilia formation.
Severin Sasso, Herwig Stibor ... Arthur R Grossman
Dubbed the 'green yeast', the model alga C. reinhardtii has profoundly advanced many areas of biology, but much remains to be learnt about its life in the wild.
Nicholas Mikolajewicz, Elizabeth A Zimmermann ... Svetlana V Komarova
Bone cells exposed to physiological forces release ATP through repairable membrane injury, generating an intercellular signal that conveys the destructive potential of forces and the adaptive capacity of endangered cells.
Catherine A Makarewich, Amir Z Munir ... Eric N Olson
Cardiac-specific overexpression of a recently discovered micropeptide, DWORF, enhances calcium cycling and contractility in the heart and rescues the heart failure phenotype of a genetic mouse model of dilated cardiomyopathy.
Mathematical and experimental analyses suggest that despite their complex architectures, multiple metazoan signaling pathways act in physiological contexts as linear signal transmitters.
Research into light-gated ion channels called channelrhodospins laid the foundations for the development of optogenetics, a technique that has gone on to revolutionize neuroscience.
