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Single-cell analysis of skeletal mouse reveals highly diverse macrophage subgroups associated with diverse functions and age-related changes.

Notch signaling in human platelets functions in noncanonical juxtacrine manner to amplify platelet reactivity and thrombogenicity.

CEP83 plays a central role in regulating the development of intermediate mesoderm (IM) nephron progenitors, which may involve direct effects of CEP83 in the nephron progenitor differentiation program and indirect lateral plate mesoderm-mediated effects on the IM.

miR-306 and miR-79 selectively eliminate JNK-activated tumors, providing a new microRNA-based strategy against cancer.

Newly identified roles for the kinesin-1 light chain subunit KLC4 in patterning developing axon arbors, regulating microtubule dynamics and influencing behavior of larval and adult zebrafish.

Neuronal glycolysis to restore energy consumed by ion movements is activated by engagement of the Na⁺/K⁺ pump, either directly by Na⁺ influx or indirectly, when Ca²⁺ influx is converted to Na⁺ accumulation by Na⁺/Ca²⁺ exchange.

The role of Isthmin-1 in muscle function is defined by using phosphoproteomics to identify distinct and overlapping signaling pathways between Isthmin-1 and insulin.

The structure of the yeast HOPS tethering complex suggests how this large complex may catalyze fusion by tethering Rab-decorated membranes and promoting the assembly of SNAREs.

A genetic manipulation of the Nrxn1/3^SS4+-Cbln1/2 complex reveals this signaling pathway has no role in synapse formation but functions to shape the NMDAR- and AMPAR-content at multiple types of synapses with distinct facets in diverse circuits.

Microfluidics and dynamic imaging allow systematic characterization of polarization kinetics in B lymphocytes and highlight the role of microtubules as master regulators of actin polymerization at the immune synapse.