Yeast cells adapt to harmful superoxide generated during mitochondrial oxidative phosphorylation by arresting respiration through mtDNA deletions whose emergence depend on superoxide dismutase 2 and the retrograde pathway.
Marlene Henríquez-Urrutia, Rebecca Spanner ... Luis F Larrondo
The biocontrol fungus Trichoderma atroviride possess a functional circadian clock, whose components impact the production of secondary metabolites and also play a role in the interaction with fungi such as the phytopathogen Botrytis cinerea.
The long-distance flight of locusts is greatly facilitated by a muscle-abundantly expressed Hif-1α splice variant, which remains active in normoxia and scavenges flight-induced reactive oxygen species by upregulating the expression of DJ-1 (PARK 7).
Campbell D Lawson, Samantha Peel ... Maddy Parsons
Nuclear fascin accumulation occurs upon inhibition of Histone H3 kinases and results in enhanced and sustained nuclear F-actin bundling leading to reduced cancer cell invasion, viability, and nuclear fascin-specific/driven apoptosis.
Prolonged β-adrenergic stimulation causes ryanodine receptor clusters to disperse, drastically altering the frequency and kinetics of Ca2+ release events called ‘Ca2+ sparks’ in a process that is dependent on CaMKII and PKA.
Genetic, proteomic, and structural analyses provide insight into the role of Brl1 during nuclear pore complex biogenesis, suggesting a function in the fusion of outer and inner nuclear membranes.
IL-33 plays an important role in the initiation of labor by leading to stress of the ER via an influx of calcium ions in human uterine smooth muscle cells.
William Conway, Robert Kiewisz ... Daniel J Needleman
A biophysical model in which kinetochore microtubules nucleate at kinetochores and growth polward along nematic streamlines quantitatively explains kinetochore microtubule lengths, orientations, and spatially varying dynamics in metaphase human spindles.
