Browse our latest Cell Biology articles

Page 89 of 314
    1. Cell Biology

    MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

    Ellen Phillips, Naseer Ahmad ... Deborah L Johnson
    Identification of a novel role for the transcriptional repressor, MAF1, and RNA polymerase III-dependent transcription, in osteoblast differentiation, mineralization, and bone biology.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    On demand expression control of endogenous genes with DExCon, DExogron and LUXon reveals differential dynamics of Rab11 family members

    Jakub Gemperle, Thomas S Harrison ... Patrick T Caswell
    DExCon, LUXon, and DExogron approaches simultaneously block endogenous gene expression and permit tuning of re-expression levels in time and space; proof-of-principle reveals unforeseen differences in protein kinetics, cargo handling, and cell migration regulation between closely related Rab11 family members.
    1. Cell Biology
    2. Neuroscience

    Intrinsic excitability mechanisms of neuronal ensemble formation

    Tzitzitlini Alejandre-García, Samuel Kim ... Rafael Yuste
    Optogenetic and electrical stimulation of primary visual cortex neurons reveals synaptic and cell-intrinsic mechanisms that underlie neuronal ensemble formation.
    1. Cell Biology
    2. Developmental Biology

    DNA-damage induced cell death in yap1;wwtr1 mutant epidermal basal cells

    Jason KH Lai, Pearlyn JY Toh ... Timothy E Saunders
    Substrate rigidity modulates genomic stress in the epidermal basal cells of the developing zebrafish embryo and Yap1 and Wwtr1 are required for its survival.
    1. Cell Biology

    Endocytic trafficking promotes vacuolar enlargements for fast cell expansion rates in plants

    Kai Dünser, Maria Schöller ... Jürgen Kleine-Vehn
    Cellular and vacuolar size expansion are coordinated.
    1. Cell Biology
    2. Medicine

    Inhibition of the sodium-dependent HCO3- transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype

    Vinciane Saint-Criq, Anita Guequén ... Carlos A Flores
    The reduction of bicarbonate secretion into the airways reproduces cystic fibrosis-like features, independently of chloride secretion.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism

    Damon JA Frampton, Koushik Choudhury ... Sara I Liin
    Polyunsaturated fatty acids facilitate or impede Kv7 channel activation, depending on channel subtype and their dominant functional site(s).
    1. Cell Biology

    Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

    Albert Pérez-Martí, Suresh Ramakrishnan ... Matias Simons
    Monounsaturated fatty acids protect against DKD by enhancing membrane fluidity and decreasing ER lipid bilayer stress in renal proximal tubules.
    1. Cancer Biology
    2. Cell Biology

    Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

    Edward Fielder, Tengfei Wan ... Satomi Miwa
    Late effects of radiation therapy in mice can be prevented by treatment with either senolytics navitoclax or quercetin plus dasatinib or the senostatic metformin.
    1. Cell Biology
    2. Immunology and Inflammation

    A B-cell actomyosin arc network couples integrin co-stimulation to mechanical force-dependent immune synapse formation

    Jia C Wang, Yang-In Yim ... John A Hammer
    B-cell integrin co-stimulation promotes the formation of an actomyosin network that drives integrin-dependent immune synapse formation and B-cell activation.