Browse our latest Cell Biology articles

Page 89 of 318
    1. Cell Biology
    2. Evolutionary Biology

    Flagellar energy costs across the tree of life

    Paul E Schavemaker, Michael Lynch
    Prokaryotic and eukaryotic flagella follow a common trend in swimming cost-effectiveness, but eukaryotic flagella are too large for cells with prokaryote volumes, yielding insight into flagellar dissimilarity between taxa.
    1. Cell Biology
    2. Physics of Living Systems

    Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5 dynamics depending on its dimerization status

    Fanny Momboisse, Giacomo Nardi ... Anne Brelot
    Combining particle tracking in living cells with statistical analysis demonstrates how the oligomeric organization of cell surface receptor influences their function, a necessary step in the development of drugs targeting specific receptor conformation.
    1. Cell Biology

    Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregation

    Alex F Thompson, Patrick R Blackburn ... Jason Stumpff
    Pathogenic mutations in KIF22, which dominantly cause bone dysplasia, improperly activate the motor during anaphase in dividing cells leading to chromosome recongression.
    1. Cancer Biology
    2. Cell Biology

    The integrated stress response remodels the microtubule-organizing center to clear unfolded proteins following proteotoxic stress

    Brian Hurwitz, Nicola Guzzi ... Elaine Fuchs
    In response to proteotoxic stress, squamous cell carcinoma cells hijack the integrated stress response to promote recovery by bolstering protection of microtubule dynamics.
    1. Cell Biology

    Ndc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth

    Michael Sean Mauro, Gunta Celma ... Shirin Bahmanyar
    Discovery of how cells couple addition of membranes with insertion of nuclear pore complexes to form and grow the nucleus.
    1. Cell Biology

    Self-assembly of pericentriolar material in interphase cells lacking centrioles

    Fangrui Chen, Jingchao Wu ... Anna Akhmanova
    In the absence of centrioles, components of pericentriolar material can self-organize into a single compact microtubule-organizing center through dynein-mediated transport of pericentrin-containing protein complexes if CAMSAP- and Golgi-mediated pathways of microtubule minus-end stabilization and anchoring are disabled.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Phosphoregulation accommodates Type III secretion and assembly of a tether of ER-Chlamydia inclusion membrane contact sites

    Rachel J Ende, Rebecca L Murray ... Isabelle Derré
    To establish membrane contacts between its vacuole and the endoplasmic reticulum, the obligate intracellular bacterial pathogen Chlamydia trachomatis has evolved complex molecular strategies to mimic emerging regulatory processes that control contact-dependent organelle–organelle communication.
    1. Cell Biology

    Adaptor linked K63 di-ubiquitin activates Nedd4/Rsp5 E3 ligase

    Lu Zhu, Qing Zhang ... Scott D Emr
    Arrestin-related trafficking adaptors (ARTs) undergo a K63 linked di-ubiquitin modification to promote Rsp5 E3 ligase recruitment and enhance cargo protein ubiquitination.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Functional requirements for a Samd14-capping protein complex in stress erythropoiesis

    Suhita Ray, Linda Chee ... Kyle J Hewitt
    Genetic complementation approaches in a mouse model of anemia reveals new protein interactions which aid cell survival and promote sensing of environmental cues.
    1. Cell Biology
    2. Genetics and Genomics

    Phosphoregulation of DSB-1 mediates control of meiotic double-strand break activity

    Heyun Guo, Ericca L Stamper ... Peter M Carlton
    Opposing activities of ATR kinase and PP4 phosphatase balance phosphorylation of the protein DSB-1 to produce sufficient but not excessive amount of DNA double-strand breaks during meiotic prophase in Caenorhabditis elegans.