Chromosomes and Gene Expression

Chromosomes and Gene Expression

eLife publishes research ranging from transcription and RNA processing to epigenetics and chromatin biology. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Chromosomes and Gene Expression
    2. Medicine

    Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells

    Karthik Amudhala Hemanthakumar et al.
    Endothelial dysfunction due to cardiovascular disease risk factors explained by cardiac endothelial cell transcriptome remodelling.
    1. Chromosomes and Gene Expression
    2. Medicine

    Cardiovascular Disease: Exploring risk factors at the molecular level

    Martina Rudnicki, Tara L Haas
    Risk factors for cardiovascular diseases trigger molecular changes that harm the endothelial cells in the heart, but exercise can suppress these effects.
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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Stress resets ancestral heritable small RNA responses

    Leah Houri-Zeevi et al.
    Various types of stress reset heritable small RNA responses through the function of the p38 MAPK pathway, the transcription factor SKN-1/Nrf2, and the MET-2/SETDB1 putative histone methyltransferase.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Increased longevity due to sexual activity in mole-rats is associated with transcriptional changes in the HPA stress axis

    Arne Sahm et al.
    The fact that sexual activity/reproduction doubles the lifespan of certain rodent species is most likely linked to critical changes in the regulation of the hypothalamic–pituitary–adrenal stress axis.
    1. Chromosomes and Gene Expression

    Promoter-specific changes in initiation, elongation, and homeostasis of histone H3 acetylation during CBP/p300 inhibition

    Emily Hsu et al.
    CBP/p300 acetylation of histone H3 at promoters and enhancers stimulates transcriptional elongation through recruitment of the super-elongation complex and BRD4.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Effective dynamics of nucleosome configurations at the yeast PHO5 promoter

    Michael Roland Wolff et al.
    The integration of multi-nucleosome configuration data with histone turnover and new chromatin accessibility data by systematically investigated 'regulated on-off-slide' models reveals promoter state transitions regulated by just one assembly process.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    A KDM5–Prospero transcriptional axis functions during early neurodevelopment to regulate mushroom body formation

    Hayden AM Hatch et al.
    The histone demethylase KDM5 functions in concert with the transcription factor Prospero to regulate a gene expression program that is required for mushroom body neuroanatomical development.
    1. Chromosomes and Gene Expression

    Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

    Nina Kirstein et al.
    Replication origins are established throughout the genome with the exception of transcribed genes, and the local chromatin composition likely modulates the density of ORC and MCM as well as origin activation.
    1. Chromosomes and Gene Expression
    2. Structural Biology and Molecular Biophysics

    Archaeal chromatin ‘slinkies’ are inherently dynamic complexes with deflected DNA wrapping pathways

    Samuel Bowerman et al.
    Archaeal histones compact DNA into nucleosome-like particles of varying sizes that contort sporadically and reorient DNA wrapping.

Senior editors

  1. Matt Kaeberlein
    University of Washington, United States
  2. Gisela Storz
    National Institute of Child Health and Human Development, United States
  3. Patricia Wittkopp
    University of Michigan, United States
  4. See more editors