Antoine Wystrach, Konstantinos Lagogiannis, Barbara Webb
Analysis of crawling Drosophila larva and agent based simulations suggest that an intrinsic rhythm rather than distinct actions underlie taxis behaviour, providing a core mechanism on which both sensory and memory pathways can converge.
Extensive benchmarking reveals that errors made when manually building models into near-atomic-resolution cryoEM density may automatically be corrected using an improved Rosetta-based structure refinement method.
Florent Meyniel, Guy M Goodwin ... Raphaël Gaillard
A selective reuptake inhibitor shows a beneficial effect in healthy humans during an effort-benefit tradeoff task, mediated at the computational level by a specific alleviation of effort cost.
Max A Horlbeck, Luke A Gilbert ... Jonathan S Weissman
Integrated modeling of sgRNA positioning, chromatin accessibility, and sequence features enables accurate prediction of effective target sites for CRISPR-mediated transcriptional modulation and design of highly active libraries for genome-scale genetic screens.
Crowding and metabolites in a simulated cellular environment alter protein conformations, modulate interactions of functionally related proteins, and lead to significant dynamic heterogeneity.
Minimal changes allow an ancestral, unfolded peptide to adopt a known fold by repetition, illuminating a possible path for the emergence of folded proteins at the origin of life.
Patrick Hillenbrand, Kerstin C Maier ... Ulrich Gerland
Quantitative analysis of time-dependent transcription data elucidates the signal processing within the genetic network that regulates transcriptional cell cycle oscillations in yeast.
Chris A Smith, Andrew D McAinsh, Nigel J Burroughs
The outer domain of the kinetochore can rotate (swivel) around the centromere, and this rather than intra-kinetochore stretching is coupled to anaphase onset.
