Browse our latest Computational and Systems Biology articles

Weak yet highly species-specific protein-protein interactions enhance the activity of metabolically related enzymes in bacteria at endogenous conditions, but also mean that overexpression of one partner leads to permanent non-physiological complexes and gene dosage toxicity.

Imaging experiments and simulations reveal that the biophysical mechanism for force generation needed to engulf a forespore is based on coordinated cell wall synthesis and degradation.

A quantitative analysis of the connectivity between photoreceptors and bipolar cells in the mouse retina based on electron microscopy data yields exceptions from established rules of outer retinal connectivity.

Ants employ a new kind of trail to resolve group-level navigational difficulties in scenarios where the information available to individuals does not suffice.

Six computationally designed and in vitro optimized protein inhibitors serve as molecular probes to reveal BCL2 profiles of different human cancers.

Quantitative dissection of the roles of chaperone binding and phosphorylation in regulating heat shock factor 1 leads to a predictive model of the dynamics of the yeast heat shock response.

The genetic background of a cancer cell and the chromatin organization of the tissue-of-origin impact the amount, length and position of somatic copy number alterations in cancer.

Theoretical models and experimental results reveal how the optimal integration of gravity cues fine tunes movement kinematics so that motor effort is minimized in the ubiquitous gravity field.

Analysis of crawling Drosophila larva and agent based simulations suggest that an intrinsic rhythm rather than distinct actions underlie taxis behaviour, providing a core mechanism on which both sensory and memory pathways can converge.