Browse our latest Computational and Systems Biology articles

Cells in the primate retina show unexpected sensitivity to approaching motion and optical flow.

Large scale virtual screening using recently solved structures of Melatonin receptors yield discovery of 10 new high-affinity selective agonists, also revealing novel functional features, including biased signaling at Melatonin receptors.

Combining experiments, bioinformatics, and mathematical modelling, we find large heterogeneity in naive T cell clone sizes.

The independent effects of transcription factor binding sites are large regardless of sequence context, but the interactions between sites are context dependent.

Wikidata is continuously-updated resource that could improve the efficiency and accuracy of research in many areas of the life and biomedical sciences.

A multi-cohort analysis of 2,500 gut microbiomes and five major diseases discovers that disease-microbiome associations display specific age-centric trends, with diseases characterized by age-centric trends of species gain/loss.

High-throughput clonal tracking quantifies intrinsic differences between primary and secondary T cell response.

Preferential endocytosis of activated receptors allows cells to memorize their past and perform relative sensing.

Kinetic interactions between sodium channels and auxiliary factors create a molecular computational engine that can sense and regulate cellular excitability.

Analysis of zebrafish periderm enhancers illuminates the conserved DNA of epithelial enhancers across species and prioritizes orofacial-cleft-associated regulatory variants near KRT18/KRT8.