Browse our latest Computational and Systems Biology articles

Page 81 of 121
    1. Computational and Systems Biology
    2. Neuroscience

    Population adaptation in efficient balanced networks

    Gabrielle J Gutierrez, Sophie Denève
    Neural populations may depend on balanced recurrent connectivity to produce an efficient stimulus representation while also maintaining an accurate stimulus encoding despite the variability introduced by adapting neural responses.
    1. Cell Biology
    2. Computational and Systems Biology

    Remote control of microtubule plus-end dynamics and function from the minus-end

    Xiuzhen Chen, Lukas A Widmer ... Yves Barral
    A mechanism for yeast centrosomes to differentiate the microtubule cytoskeleton.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Consistent and correctable bias in metagenomic sequencing experiments

    Michael R McLaren, Amy D Willis, Benjamin J Callahan
    A mathematical model of bias in marker-gene and metagenomic sequencing measurements explains systematic errors in defined mixtures of microbial species, and enables quantitative and reproducible investigation of biological communities.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Deep generative models for T cell receptor protein sequences

    Kristian Davidsen, Branden J Olson ... Frederick A Matsen IV
    Deep learning improves estimation of T cell receptor cohort frequencies and learns the rules of VDJ recombination, potentially making it helpful for vaccine design.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Correlated evolution between repertoire size and song plasticity predicts that sexual selection on song promotes open-ended learning

    Cristina M Robinson, Kate T Snyder, Nicole Creanza
    A longer birdsong-learning window evolves in response to sexual selection for song complexity and is associated with faster evolution of song performance characteristics.
    1. Computational and Systems Biology
    2. Neuroscience

    Statistical context dictates the relationship between feedback-related EEG signals and learning

    Matthew R Nassar, Rasmus Bruckner, Michael J Frank
    The P300, an electroencephalography (EEG) component known to be evoked by surprising events, predicts learning in a bidirectional manner that depends critically on the surrounding statistical context.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolution of asymmetric gamete signaling and suppressed recombination at the mating type locus

    Zena Hadjivasiliou, Andrew Pomiankowski
    Selection for asymmetric signalling between gametes explains the very origins of sexual asymmetry as seen in mating-types with morphologically similar but self-incompatible gametes.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Self-organised segregation of bacterial chromosomal origins

    Andreas Hofmann, Jarno Mäkelä ... Seán M Murray
    The self-organising condensin MukBEF positions chromosomal origins in Escherichia coli..
    1. Computational and Systems Biology
    2. Neuroscience

    Multivariate stochastic volatility modeling of neural data

    Tung D Phan, Jessica A Wachter ... Michael J Kahana
    Multivariate stochastic volatility models provide insights into understanding the dynamics and connectivity of neural signals during cognitive tasks.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Profiling the Escherichia coli membrane protein interactome captured in Peptidisc libraries

    Michael Luke Carlson, R Greg Stacey ... Franck Duong Van Hoa
    Trapping of the cell envelope proteome into water-soluble peptidisc library allows high-throughput definition of the membrane protein interactome.