Browse our latest Computational and Systems Biology articles

Theoretical analysis uncovers the impact of axon initial segment plasticity on neural excitability.

The molecular insight in lipoplex transfection mechanisms helps in the development of efficient and affordable gene delivery systems.

By combining structure-based computational predictions and a thorough structural analysis, a highly thermostable enzyme, alcohol dehydrogenase, has been engineered.

Direct estimation of the Hurst exponent shows that endosomes and lysosomes reside in regimes of persistent and anti-persistent motion with heavy-tailed residence time distributions and motion correlated with endocytic function.

Measurement of the distribution of fitness effects of new mutations arising in human oesophagus and skin, via new mathematical theory linking dn/ds values and fitness coefficients.

Usage-dependent inhibition breakdown and neural adaptation underpins the key spatiotemporal dynamics of human focal seizures.

Cells in the primate retina show unexpected sensitivity to approaching motion and optical flow.

Large scale virtual screening using recently solved structures of Melatonin receptors yield discovery of 10 new high-affinity selective agonists, also revealing novel functional features, including biased signaling at Melatonin receptors.

Combining experiments, bioinformatics, and mathematical modelling, we find large heterogeneity in naive T cell clone sizes.

The independent effects of transcription factor binding sites are large regardless of sequence context, but the interactions between sites are context dependent.