Browse our latest Developmental Biology articles

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    1. Developmental Biology

    Forkhead transcription factor FKH-8 cooperates with RFX in the direct regulation of sensory cilia in Caenorhabditis elegans

    Rebeca Brocal-Ruiz, Ainara Esteve-Serrano ... Nuria Flames
    In sensory ciliated neurons, FoxN4 Forkhead (FKH) transcription factors directly coregulate transcription of ciliome genes together with RFX transcription factors, a similar regulatory logic to what is found for motile-cilium cell types, suggesting an ancestral origin for this partnership.
    1. Developmental Biology

    Embryo-derive TNF promotes decidualization via fibroblast activation

    Si-Ting Chen, Wen-Wen Shi ... Zeng-Ming Yang
    Embryo-derived TNF promotes CPLA phosphorylation and arachidonic acid release from luminal epithelium to induce fibroblast activation and decidualization.
    1. Developmental Biology
    2. Genetics and Genomics

    Breaking enhancers to gain insights into developmental defects

    Daniel A Armendariz, Anjana Sundarrajan, Gary C Hon
    Continuing advances in functional genomics will enable systematic characterization of how non-coding genetic variation at enhancers impacts developmental diseases.
    1. Computational and Systems Biology
    2. Developmental Biology

    How enhancers regulate wavelike gene expression patterns

    Christine Mau, Heike Rudolf ... Ezzat El-Sherif
    An experimental and computational system has been developed to investigate how wavelike gene expression patterns are generated during embryonic development.
    1. Developmental Biology
    2. Evolutionary Biology

    Epigenetically distinct synaptic architecture in clonal compartments in the teleostean dorsal pallium

    Yasuko Isoe, Ryohei Nakamura ... Hiroyuki Takeda
    The dorsal telencephalon (pallium) in medaka fish accommodates an epigenetically distinct brain area that selectively regulates unique set of synaptic genes compared to the surrounding pallial region, providing insights into the evolution of the pallium in vertebrate.
    1. Developmental Biology
    2. Neuroscience

    Multifunctional requirements for ERK1/2 signaling in the development of ganglionic eminence derived glia and cortical inhibitory neurons

    Sara J. Knowles, Michael C. Holter ... Jason M. Newbern
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Multiple repeat regions within mouse DUX recruit chromatin regulators to facilitate an embryonic gene expression program

    Christina M. Smith, Edward J. Grow ... Bradley R. Cairns
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Cell Biology
    2. Developmental Biology

    Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset

    Arian Mansur, Remi Joseph ... Vandana A Gupta
    Novel disease pathways underlie disease pathogenesis in Kelch-related nemaline myopathy through proteomic remodeling.
    1. Developmental Biology

    The Drosophila Nab2 RNA binding protein inhibits m6A methylation and male-specific splicing of Sex lethal transcript in female neuronal tissue

    Binta Jalloh, Carly L Lancaster ... Ken Moberg
    The disease-associated RNA binding protein Nab2 is required to inhibit m6A RNA methylation in female Drosophila neuronal tissue and controls key splicing events such as sex-specific splicing of the Sex-lethal RNA.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation

    Francisco X Galdos, Carissa Lee ... Sean M Wu
    TBX5 lineage tracing and high resolution single cell transcriptomics uncover the predominance of first heart field development during human-induced pluripotent stem cell cardiac differentiation.