Joshua S Greene, May Dobosiewicz ... Cornelia I Bargmann
A quantitative trait locus that includes two pheromone receptor genes affects foraging behavior; for one of the genes, the two alleles of the QTL have opposite effects because of distinct sites of expression.
Yehudit Hasin-Brumshtein, Arshad H Khan ... Desmond J Smith
In depth characterization of gene expression in the mouse hypothalamus will facilitate understanding of the molecular pathways that affect metabolic traits and discovers new genes associated with these pathways.
Computational analysis of MNase-seq data reveals that alternatively positioned nucleosomes are prevalent in both yeast and human cells and create significant heterogeneity within cell populations.
Andrew T Timberlake, Jungmin Choi ... Richard P Lifton
Epistatic interactions of rare loss of function mutations in SMAD6 and a common variant modifier near BMP2 are the most common cause of midline craniosynostosis in humans.
Mutations affecting a nuclear encoded metalloprotease cause of a new form of mitochondriopathy, highlighting the importance of this protease for mitochondrial function in humans.
Whole genome DNA sequence analysis, genome wide gene expression and complex organismal phenotypes in Drosophila mutation accumulation lines provide a robust estimate of the spontaneous mutation rate and mutational effects.