Browse our latest Genetics and Genomics articles

Page 75 of 144
    1. Genetics and Genomics
    2. Neuroscience

    Neuronal calmodulin levels are controlled by CAMTA transcription factors

    Thanh Thi Vuong-Brender, Sean Flynn ... Mario de Bono
    CAMTA transcription factors are evolutionarily conserved regulators of neuronal levels of the major Ca2+ sensor calmodulin.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Ancient Viruses: How infectious diseases arrived in the colonial Americas

    Ville N Pimenoff, Charlotte J Houldcroft
    Analysis of viral DNA from human remains suggests that the transatlantic slave trade may have introduced new pathogens that contributed to the devastating disease outbreaks in colonial Mexico.
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    1. Developmental Biology
    2. Genetics and Genomics

    Cardiac pathologies in mouse loss of imprinting models are due to misexpression of H19 long noncoding RNA

    Ki-Sun Park, Beenish Rahat ... Karl Pfeifer
    Maternal loss of imprinting at the Igf2/H19 locus reduces expression of H19 lncRNA and thereby leads to progressive cardiac pathologies in a mouse Beckwith–Wiedemann syndrome model.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Ancient viral genomes reveal introduction of human pathogenic viruses into Mexico during the transatlantic slave trade

    Axel A Guzmán-Solís, Viridiana Villa-Islas ... María C Ávila Arcos
    The characterization of ancient B19V and HBV genotype A4 viruses circulating during Colonial epidemics provides new insights into the pathogens that were introduced to the Americas after the European colonization.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Evolution of cytokine production capacity in ancient and modern European populations

    Jorge Domínguez-Andrés, Yunus Kuijpers ... Mihai G Netea
    Neolithic was a turning point for immune responses in Europeans, favoring tolerance against intracellular pathogens, promoting inflammation against extracellular microbes, and being related to current auto-immune diseases.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A precisely adjustable, variation-suppressed eukaryotic transcriptional controller to enable genetic discovery

    Asli Azizoglu, Roger Brent, Fabian Rudolf
    A new gene expression tool enables precise control of protein dosage over a large range and paves the way for new genetic discoveries.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Uniparental nuclear inheritance following bisexual mating in fungi

    Vikas Yadav, Sheng Sun, Joseph Heitman
    Discovery of a novel mode of sexual reproduction, termed pseudosexual reproduction, in fungi where both parents are required for mating but only one contributes to the meiotic progeny, similar to hybridogenesis in animals.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Understanding patterns of HIV multi-drug resistance through models of temporal and spatial drug heterogeneity

    Alison F Feder, Kristin N Harper ... Pleuni S Pennings
    In triple-drug-treated HIV, partially resistant viruses can spread and resistance to specific drugs evolves in a predictable order, potentially a result of spatial or temporal heterogeneity in drug concentrations.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Mutational sources of trans-regulatory variation affecting gene expression in Saccharomyces cerevisiae

    Fabien Duveau, Petra Vande Zande ... Patricia J Wittkopp
    Mapping mutations affecting gene expression within the yeast genome and within a gene regulatory network reveals properties of the raw material for regulatory variation.
    1. Genetics and Genomics
    2. Immunology and Inflammation

    Single-cell analysis of mosquito hemocytes identifies signatures of immune cell subtypes and cell differentiation

    Hyeogsun Kwon, Mubasher Mohammed ... Ryan C Smith
    Single-cell RNA-seq analysis reveals an increased complexity of mosquito hemocytes, enabling the functional and molecular characterization of immune cell sub-populations in Anopheles gambiae.