Genetics and Genomics

Latest articles

1. 1. Chromosomes and Gene Expression
   2. Genetics and Genomics

   DNA methylation insulates genic regions from CTCF loops near nuclear speckles

   Shelby A Roseman, Allison P Siegenfeld ... Brian B Liau

   CTCF binding promotes chromatin-nuclear speckle interactions and gene activation after DNA demethylation, yet its binding and looping patterns are unaffected by speckle depletion.
2. 1. Genetics and Genomics

   WRN and WRNIP1 ATPases impose high fidelity on translesion synthesis by Y-family DNA polymerases

   Jung Hoon Yoon, Karthi Sellamuthu ... Satya Prakash

   WRN and WRNP1 ATPases together with WRN 3’ to 5’ exonuclease raise the fidelity of intrinsically highly error-prone Y-family DNA polymerases such that they perform error-free translesion synthesis.
3. 1. Genetics and Genomics

   Gene expression variation across genetically identical individuals predicts reproductive traits

   Amy K Webster, John H Willis ... Patrick C Phillips

   Differences among genetically identical individuals can be explained using expression levels of just a handful of genes, suggesting that environmental variation can be functionally analyzed.
4. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans

   Rajneesh Rao, Alejandro Aballay, Jogender Singh
5. 1. Genetics and Genomics

   Identifying in vivo genetic dependencies of melanocyte and melanoma development

   Sarah Perlee, Yilun Ma ... Richard M White

   A zebrafish Cas9 knock-in model enables lineage-specific gene disruption to uncover genetic dependencies in development and disease.
6. 1. Cancer Biology
   2. Genetics and Genomics

   NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors

   Connor Hill, Alexandra Indeglia ... Alessandro Gardini

   Molecular profiling with omics approaches reveals the resemblance between neuroendocrine malignancies and solitary fibrous tumors, rare soft tissue cancers with no effective treatment options.
7. 1. Genetics and Genomics

   Functional characterization of the disease-associated CCL2 rs1024611G-rs13900T haplotype: The role of the RNA-binding protein HuR

   Feroz Akhtar, Joselin Hernandez Ruiz ... Srinivas Mummidi
8. 1. Genetics and Genomics
   2. Microbiology and Infectious Disease

   Neisseria gonorrhoeae LIN codes: a Robust, Multi-Resolution Lineage Nomenclature

   Anastasia Unitt, Made Krisna ... Odile B Harrison
9. 1. Genetics and Genomics

   ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB-mediated signaling pathway in humans and mice

   Chong Chen, Qian Liu ... Xinting Liu

   The unbiased genetic screening and animal model experiments have characterized a new candidate pathogenic gene associated with high myopia, providing a potential therapeutic intervention target for controlling the disease.
10. 1. Genetics and Genomics
    2. Medicine

    Heterozygous variants in PLCG1 affect hearing, vision, cardiac, and immune function

    Mengqi Ma, Yiming Zheng ... Undiagnosed Diseases Network

    Clinical, genetic, and model organism data collectively define PLCG1 as a disease-associated gene with diverse missense variants contributing to phenotypic heterogeneity.