Genetics and Genomics

Latest articles

1. 1. Genetics and Genomics

   Dynamics and regulatory roles of RNA m⁶A methylation in unbalanced genomes

   Shuai Zhang, Ruixue Wang ... Lin Sun

   Global analyses using aneuploid Drosophila revealed the dynamic roles of RNA m⁶A modification in regulating gene expression and development under genomic imbalance, highlighting its potential relationships with dosage-related effects.
2. 1. Computational and Systems Biology
   2. Genetics and Genomics

   Risk factors affecting polygenic score performance across diverse cohorts

   Daniel Hui, Scott Dudek ... Marylyn D Ritchie

   Numerous related sample characteristics affect polygenic score performance, and incorporation of interaction effects increases both model and polygenic score performance.
3. 1. Genetics and Genomics
   2. Evolutionary Biology

   Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments

   Christopher S McAllester, John E Pool
4. 1. Genetics and Genomics
   2. Neuroscience

   Zinc finger homeobox-3 (ZFHX3) orchestrates genome-wide daily gene expression in the suprachiasmatic nucleus

   Akanksha Bafna, Gareth Banks ... Patrick M Nolan
5. 1. Genetics and Genomics

   Down Syndrome: How a gene fuels ear infections

   Sedigheh Delmaghani, Aziz El-Amraoui

   The DYRK1A enzyme is a pivotal contributor to frequent and severe episodes of otitis media in Down syndrome, positioning it as a promising target for therapeutic interventions.
6. 1. Genetics and Genomics
   2. Neuroscience

   Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation

   Tanya Wolff, Mark Eddison ... Gerald M Rubin
7. 1. Genetics and Genomics
   2. Immunology and Inflammation

   Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant

   Patsy R Tomlinson, Rachel G Knox ... Robert K Semple

   PIK3R1 mutations that cause immunodeficiency through PI3-kinase hyperactivation also cause SHORT syndrome, due to PI3-kinase hypofunction, attributable to PI3-kinase destabilisation and outcompetition by mutant PIK3R1.
8. 1. Developmental Biology
   2. Genetics and Genomics

   Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers

   Svanhild Nornes, Susann Bruche ... Sarah De Val
9. 1. Genetics and Genomics

   Mettl5 coordinates protein production and degradation of PERIOD to regulate sleep in Drosophila

   Xiaoyu Wu, Xingzhuo Yang ... Juan Du
10. 1. Genetics and Genomics
    2. Computational and Systems Biology

    Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA Stability

    Jia-Ying Su, Yun-Lin Wang ... Chien-Ling Lin