Genomics and Evolutionary Biology

eLife publishes research spanning adaptation, morphology, bioinformatics and comparative genomics. Decisions are made by journal editors who are active researchers in the fields of genomics and/or evolutionary biology.
Illustration by Davide Bonazzi

Latest articles

    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Dynamics of genomic innovation in the unicellular ancestry of animals

    Xavier Grau-Bové et al.
    The foundations of genomic complexity in multicellular animals have deep roots in their unicellular prehistory, both in terms of innovations in gene content, as well as the evolutionary dynamics of genome architecture.
    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    Mobilization of LINE-1 retrotransposons is restricted by Tex19.1 in mouse embryonic stem cells

    Marie MacLennan et al.
    Post-translational regulation of retrotransposons plays a key role in preventing retrotransposon mobilization in the epigenetically dynamic mouse germline.
    1. Developmental Biology and Stem Cells
    2. Genomics and Evolutionary Biology

    Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression

    Daniel Andergassen et al.
    Allele-specific expression due to genetic differences, X-chromosome inactivation or genomic imprinting, varies dynamically throughout development, and may be explained by allele-specific differences in stability or the actions of tissue-specific enhancers.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    Uncoupling evolutionary changes in DNA sequence, transcription factor occupancy and enhancer activity

    Pierre Khoueiry et al.
    Interspecies comparison of transcription factor occupancy during embryogenesis reveals potential co-operative relationships between factors and uncovers the inherent plasticity of developmental enhancers to overcome divergence in transcription factor occupancy.
    1. Genes and Chromosomes
    2. Genomics and Evolutionary Biology

    CRISPR-mediated genetic interaction profiling identifies RNA binding proteins controlling metazoan fitness

    Adam D Norris et al.
    Synthetic genetic analysis in C. elegans identifies pairs of RNA binding protein genes that play a critical role in organism health and development.
    1. Computational and Systems Biology
    2. Genomics and Evolutionary Biology

    Systematic bacterialization of yeast genes identifies a near-universally swappable pathway

    Aashiq H Kachroo et al.
    Despite billions of years of divergence, a majority of prokaryotic genes can functionally replace their essential eukaryotic counterparts, revealing broad preservation of ancestral functions and identifying heme biosynthesis as a near-universally swappable pathway.
    1. Genomics and Evolutionary Biology
    2. Microbiology and Infectious Disease

    Extensive horizontal gene transfer in cheese-associated bacteria

    Kevin S Bonham et al.
    The identification of horizontally transferred genes, and commonly transferred functions, can provide a window into the selective forces acting on species within an ecosystem.

Senior editors

  1. Aviv Regev
    Aviv Regev
    Senior Editor
  2. Diethard Tautz
    Diethard Tautz
    Senior Editor
  3. Patricia Wittkopp
    Patricia Wittkopp
    Senior Editor
  4. See more editors