Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Genetics and Genomics
    2. Evolutionary Biology

    The integrated WF-Haldane (WFH) model of genetic drift resolving the many paradoxes of molecular evolution

    Yongsen Ruan, Xiaopei Wang ... Chung-I Wu
    Revised
    Reviewed Preprint v2
    Updated
    1. Genetics and Genomics

    Intergenerational transport of double-stranded RNA in C. elegans can limit heritable epigenetic changes

    Nathan Shugarts, Aishwarya Sathya ... Antony M Jose
    Revised
    Reviewed Preprint v2
    Updated
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    High resolution deep mutational scanning of the melanocortin-4 receptor enables target characterization for drug discovery

    Conor J Howard, Nathan S Abell ... Nathan B Lubock
    Not revised
    Reviewed Preprint v1
    1. Cell Biology
    2. Genetics and Genomics

    Full-length direct RNA sequencing uncovers stress granule-dependent RNA decay upon cellular stress

    Showkat Ahmad Dar, Sulochan Malla ... Manolis Maragkakis
    Cellular stress induces RNA decay that depends on stress granule assembly and is mediated by XRN1, independent of poly(A) tail and 5' cap removal.
    1. Genetics and Genomics
    2. Neuroscience

    Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics

    Thomas P Spargo, Lachlan Gilchrist ... Alfredo Iacoangeli
    Pleiotropic loci that play a role in multiple neuropsychiatric diseases exist, but many of them might contribute to each disease via a distinct mechanism.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model

    Arkadiy K Golov, Alexey A Gavrilov ... Sergey V Razin
    A new genomic method called MChIP-C measures H3K4me3-associated chromatin interactions with extremely high resolution and sensitivity, detecting interactions in over 60% of functionally verified enhancer-promoter pairs.
    1. Genetics and Genomics

    UBR-1 deficiency leads to ivermectin resistance in C. elegans

    Yi Li, Long Gong ... Shangbang Gao
    Not revised
    Reviewed Preprint v1
    1. Genetics and Genomics

    Dimeric R25CPTH(1-34) Activates the Parathyroid Hormone-1 Receptor in vitro and Stimulates Bone Formation in Osteoporotic Female Mice

    Minsoo Noh, Xiangguo Che ... Sihoon Lee
    Revised
    Reviewed Preprint v2
    Updated
    1. Genetics and Genomics

    Systematic creation and phenotyping of Mendelian disease models in C. elegans: towards large-scale drug repurposing

    Thomas J O’Brien, Ida L Barlow ... André EX Brown
    Revised
    Reviewed Preprint v3
    Updated
    1. Genetics and Genomics
    2. Evolutionary Biology

    Template switching during DNA replication is a prevalent source of adaptive gene amplification

    Julie N Chuong, Nadav Ben Nun ... David Gresham
    Revised
    Reviewed Preprint v2
    Updated
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    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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    1. Genetics and Genomics
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    1. Genetics and Genomics

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Senior editors

  1. Murim Choi
    Seoul National University College of Medicine, South Korea
  2. Sacha B Nelson
    Brandeis University, United States
  3. Wei Yan
    Washington State University, United States
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