Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Major nuclear locales define nuclear genome organization and function beyond A and B compartments

    Omid Gholamalamdari, Tom van Schaik ... Andrew S Belmont
    New insights into nuclear genome organization were generated by comparing genome localization relative to three major nuclear locales- nuclear lamina, nuclear speckles, and nucleoli- across several human cell lines.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Deep sequencing of yeast and mouse tRNAs and tRNA fragments using OTTR

    Hans Tobias Gustafsson, Lucas Ferguson ... Oliver J Rando
    1. Cell Biology
    2. Genetics and Genomics

    Assessment of the Histone Mark-based Epigenomic Landscape in Human Myometrium at Term Pregnancy

    San-Pin Wu, Elvis Quiroz ... Francesco J DeMayo
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cell Biology
    2. Genetics and Genomics

    Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma

    Keva Li, Nicholas Tolman ... UK Biobank Eye and Vision Consortium
    Pyruvate and related metabolites are linked to reduced glaucoma risk among genetically predisposed individuals and mitigate disease in a mouse model, highlighting a potential metabolic mechanism of resilience.
    1. Developmental Biology
    2. Genetics and Genomics

    Single-cell transcriptomics of X-ray irradiated Drosophila wing discs reveals heterogeneity related to cell-cycle status and cell location

    Joyner Cruz, Willam Y Sun ... Iswar K Hariharan
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Household clustering and seasonal genetic variation of Plasmodium falciparum at the community-level in The Gambia

    Marc-Antoine Guery, Sukai Ceesay ... Antoine Claessens
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Developmental Biology
    2. Genetics and Genomics

    Coordinated Tbx3/Tbx5 transcriptional control of the adult ventricular conduction system

    Ozanna Burnicka-Turek, Katy A Trampel ... Ivan P Moskowitz
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics

    Convergent evolution of epigenome recruited DNA repair across the Tree of Life

    J Grey Monroe, Chaehee Lee ... Daniel Runcie
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cancer Biology
    2. Genetics and Genomics

    Combinatorial CRISPR screen reveals FYN and KDM4 as targets for synergistic drug combination for treating triple negative breast cancer

    Tackhoon Kim, Byung-Sun Park ... Timothy Lu
    Pairwise CRISPR screen identified FYN and KDM4 as key regulator of tyrosine kinase inhibitor resistance in triple negative breast cancer (TNBC).
    1. Genetics and Genomics
    2. Neuroscience

    Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation

    Tanya Wolff, Mark Eddison ... Gerald M Rubin
    Genetic tools were generated and used to determine the neurotransmitters and neuropeptides used by individual cell types within the Drosophila central complex and to study their roles in sleep regulation.
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Highlights

    1. Genetics and Genomics
    2. Neuroscience

    Targeting single neurons

    Brandon L Holder, Stephane Dissel
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

    Submit to our latest special issue in systems genetics

    1. Genetics and Genomics
    2. Neuroscience
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Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Alan Moses
    University of Toronto, Canada
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