Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    Inhibition of mitochondrial protein import and proteostasis by a pro-apoptotic lipid

    Josep Fita-Torró, José Luis Garrido-Huarte ... Markus Proft
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Cancer Biology

    Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity

    Hirokazu Kimura, Kamel Lahouel ... Nicholas J Roberts
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Control of pili synthesis and putrescine homeostasis in Escherichia coli

    Iti Mehta, Jacob B Hogins ... Larry Reitzer
    Putrescine has a homeostatic network that controls pili synthesis and energy metabolism.
    1. Genetics and Genomics
    2. Evolutionary Biology

    Lifestyles shape genome size and gene content in fungal pathogens

    Anna Fijarczyk, Pauline Hessenauer ... Christian R Landry
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Genetics and Genomics

    Molecular Requirements for C. elegans Transgenerational Epigenetic Inheritance of Pathogen Avoidance

    Rachel Kaletsky, Rebecca Moore ... Coleen T Murphy
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Compelling
    1. Genetics and Genomics

    UBR-1 deficiency leads to ivermectin resistance in Caenorhabditis elegans

    Yi Li, Long Gong ... Shangbang Gao
    Behavioral and functional analyses revealed that UBR-1 deficiency in Caenorhabditis elegans disrupts glutamate signaling and confers ivermectin resistance.
    1. Genetics and Genomics
    2. Neuroscience

    Drosophila epidermal cells are intrinsically mechanosensitive and modulate nociceptive behavioral outputs

    Jiro Yoshino, Sonali S Mali ... Jay Z Parrish
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Genetics and Genomics

    Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma

    Keva Li, Nicholas Tolman ... UK Biobank Eye and Vision Consortium
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    Fast evolutionary turnover and overlapping variances of sex-biased gene expression patterns defy a simple binary classification of sexes

    Chen Xie, Sven Künzel, Diethard Tautz
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Solid
    1. Genetics and Genomics

    Dimeric R25CPTH(1–34) activates the parathyroid hormone-1 receptor in vitro and stimulates bone formation in osteoporotic female mice

    Minsoo Noh, Xiangguo Che ... Sihoon Lee
    A novel mutant, R25CPTH, derived from a hypoparathyroidism patient, can form a dimer that activates PTH1R and enhances bone formation in female mice similar to PTH despite altered molecular properties.
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Highlights

    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology
    3. Genetics and Genomics

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    1. Genetics and Genomics

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Senior editors

  1. Kathryn Cheah
    The University of Hong Kong, Hong Kong SAR China
  2. Murim Choi
    Seoul National University College of Medicine, South Korea
  3. Dominique Soldati-Favre
    University of Geneva, Switzerland
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