Genetics and Genomics

Genetics and Genomics

eLife reviews research including the genetic basis of health and disease, epigenetics, genomics, medical genetics, genetic epidemiology, and population genetics. Learn more about what we review and sign up for the latest research.
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Latest articles

    1. Cancer Biology
    2. Genetics and Genomics

    NAB2-STAT6 drives an EGR1-dependent neuroendocrine program in solitary fibrous tumors

    Connor Hill, Alexandra Indeglia ... Alessandro Gardini
    Molecular profiling with omics approaches reveals the resemblance between neuroendocrine malignancies and solitary fibrous tumors, rare soft tissue cancers with no effective treatment options.
    1. Genetics and Genomics

    Functional characterization of the disease-associated CCL2 rs1024611G-rs13900T haplotype: The role of the RNA-binding protein HuR

    Feroz Akhtar, Joselin Hernandez Ruiz ... Srinivas Mummidi
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Neisseria gonorrhoeae LIN codes: a Robust, Multi-Resolution Lineage Nomenclature

    Anastasia Unitt, Made Krisna ... Odile B Harrison
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
    1. Genetics and Genomics

    ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB-mediated signaling pathway in humans and mice

    Chong Chen, Qian Liu ... Xinting Liu
    The unbiased genetic screening and animal model experiments have characterized a new candidate pathogenic gene associated with high myopia, providing a potential therapeutic intervention target for controlling the disease.
    1. Genetics and Genomics
    2. Medicine

    Heterozygous variants in PLCG1 affect hearing, vision, cardiac, and immune function

    Mengqi Ma, Yiming Zheng ... Undiagnosed Diseases Network
    Clinical, genetic, and model organism data collectively define PLCG1 as a disease-associated gene with diverse missense variants contributing to phenotypic heterogeneity.
    1. Genetics and Genomics
    2. Neuroscience

    The hypoxic response extends lifespan through a bioaminergic and peptidergic neural circuit

    Elizabeth S Kitto, Shijiao Huang ... Scott F Leiser
    Not revised
    Reviewed Preprint v1
    • Fundamental
    • Convincing
    1. Genetics and Genomics
    2. Neuroscience

    Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain

    Tom Bonnifet, Sandra Sinnassamy ... Julia Fuchs
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Genetics and Genomics
    2. Neuroscience

    Transcriptional responses to chronic oxidative stress require cholinergic activation of G-protein-coupled receptor signaling

    Kasturi Biswas, Caroline Moore ... Michael M Francis
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Genetics and Genomics
    2. Evolutionary Biology

    Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and disease

    Yao-Chung Chen, Arnaud Maupas, Katja Nowick
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Genetics and Genomics
    2. Neuroscience

    Single-cell transcriptome sequencing for opening the blood-brain barrier through specific mode electroacupuncture stimulation

    Congcong Ma, Zhaoxing Jia ... Xianming Lin
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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    1. Biochemistry and Chemical Biology
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    3. Genetics and Genomics

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    1. Genetics and Genomics

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Senior editors

  1. Murim Choi
    Seoul National University College of Medicine, South Korea
  2. Yamini Dalal
    National Cancer Institute, United States
  3. Wei Yan
    Washington State University, United States
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