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Latest articles

    1. Medicine

    Serum, Cell-Free, HPV-Human DNA Junction Detection and HPV Typing for Predicting and Monitoring Cervical Cancer Recurrence

    Anne Van Arsdale, Olga Mescheryakova ... Jack Lenz
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cancer Biology
    2. Medicine

    Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis

    Yiran Zhang, Hanyang Guan ... Jinghua Pan
    Patients with microsatellite stable/low microsatellite instability mismatch repair-proficient metastatic colorectal cancer may be sensitive to tislelizumab treatment after receiving Gamma Knife stereotactic radiotherapy.
    1. Medicine

    Addressing cultural and knowledge barriers to enable preclinical sex inclusive research

    Brianna N Gaskill, Benjamin Phillips ... Natasha A Karp
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Medicine

    Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging

    Duilio M Potenza, Xin Cheng ... Xiu-Fen Ming
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Medicine

    Aging: Multiple roles for a mitochondrial enzyme

    Xicong Tang, Hongyu Qiu
    The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.
    Version of Record
    Insight
    1. Medicine

    Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans

    Yifan Xiang, Vineeta Tanwar ... Pankaj Kapahi
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Medicine

    The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming

    Zachary W Grimmett, Rongli Zhang ... Jonathan S Stamler
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Medicine
    2. Computational and Systems Biology

    Calibration and validation strategy for electromechanical cardiac digital twins

    Zhinuo Jenny Wang, Maxx Holmes ... Blanca Rodriguez
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Medicine
    2. Immunology and Inflammation

    C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

    Toru Tanaka, Naoto Sasaki ... Yoshiyuki Rikitake
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Incomplete
    1. Medicine
    2. Neuroscience

    Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2

    Joanna Kosinska, Julian C Assmann ... Markus Schwaninger
    The therapeutic effect of dimethyl fumarate in experimental autoimmune encephalomyelitis depends on the diet of mice and is mediated by the G protein-coupled receptor HCAR2 in neutrophils.
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Highlights

    1. Medicine

    Enzymes and cardiac aging

    Xicong Tang, Hongyu Qiu
    1. Epidemiology and Global Health
    2. Medicine
    3. Microbiology and Infectious Disease

    Explore the latest COVID-19 research

    Edited by Diane M Harper et al.
    1. Medicine

    Meet our new Senior Editors in Medicine

Senior editors

  1. Matthias Barton
    University of Zurich, Switzerland
  2. Caigang Liu
    Shengjing Hospital of China Medical University, China
  3. Jonathan Roiser
    University College London, United Kingdom
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