Human Biology and Medicine

Human Biology and Medicine

eLife publishes research in clinical and translational research, human genetics, cancer, diabetes and developmental disorders. Learn more about what we publish and sign up for the latest research.
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Latest articles

    1. Human Biology and Medicine
    2. Microbiology and Infectious Disease

    Rare missense variants in the human cytosolic antibody receptor preserve antiviral function

    Jingwei Zeng et al.
    Studying the impact of natural variation on a key immune gene highlights how focusing on a single wild-type sequence overlooks that rare variants cause the most disease.
    1. Human Biology and Medicine

    Stimulation of Piezo1 by mechanical signals promotes bone anabolism

    Xuehua Li et al.
    Mechanical stimuli activate Piezo1 in osteoblast lineage cells and thereby promote bone formation in part via Wnt1.
    1. Cell Biology
    2. Human Biology and Medicine

    Bone Formation: Sensing the load

    Nele Haelterman, Joohyun Lim
    How does the skeleton detect and adapt to changes in the mechanical load it has to carry?
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    1. Cell Biology
    2. Human Biology and Medicine

    Myogenic vasoconstriction requires G12/G13 and LARG to maintain local and systemic vascular resistance

    Ramesh Chennupati et al.
    Genetic mouse models identify a critical mechanism of myogenic vasoconstriction and reveal the in vivo function of myogenic autoregulation in protecting from organ overperfusion and in maintaining vascular resistance.
    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

    Kevin Achberger et al.
    A microphysiological system (retina-on-a-chip) shows the potential to promote drug development and provide new insights into the underlying pathology of retinal diseases.
    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Tissue Engineering: Building a better model of the retina

    Milica Radisic
    Researchers have combined organ-on-a-chip engineering with the benefits of organoids to make improved models of the human retina.
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    1. Human Biology and Medicine
    2. Immunology and Inflammation

    ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

    Thomas Scambler et al.
    Dysfunction and overexpression of ENaC-mediated sodium influx exacerbates activation of NLRP3-inflammasome mediated inflammation in cells with CF-associated mutations and is modulated by inhibition of these amiloride-sensitive sodium (Na+) channels.

Senior editors

  1. Eduardo Franco
    McGill University, Canada
  2. Clifford Rosen
    Maine Medical Center Research Institute, United States
  3. Huda Zoghbi
    Huda Zoghbi
    Texas Children's Hospital, United States
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