Medicine

Latest articles

1. 1. Medicine
   2. Immunology and Inflammation

   Kynurenine monooxygenase blockade reduces endometriosis-like lesions, improves visceral hyperalgesia, and rescues mice from a negative behavioural phenotype in experimental endometriosis

   Ben Higgins, Ioannis Simitsidellis ... Damian J Mole
2. 1. Medicine

   Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

   Yanling Huang, Haocong Mo ... Geyang Xu

   Experimental results suggest a previously unknown regulatory mechanism for GLP-1 production in L cells, which could offer new insights into diabetes treatments.
3. 1. Medicine
   2. Computational and Systems Biology

   Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations

   Xin Zhou, Zhinuo Jenny Wang ... Blanca Rodriguez
4. 1. Medicine

   The zinc transporter Slc30a1 (ZnT1) in macrophages plays a protective role against attenuated Salmonella

   Pinanong Na-Phatthalung, Shumin Sun ... Fudi Wang

   Zinc transporter Slc30a1 mediates antibacterial defense in macrophages.
5. 1. Medicine

   Time to Eat - A Personalized Circadian Eating Schedule Leads to Weight Loss Without Calorie Restriction: A Randomized Controlled Trial

   Isabell Wilming, Jana Tuschewski ... Dominic Landgraf
6. 1. Chromosomes and Gene Expression
   2. Medicine

   LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling

   Xianghong Xie, Mingyue Gao ... Xiaojun Liu

   LncRNA-Snhg3 regulates lipid metabolism by affecting chromatin accessibility which indicates that lncRNA-mediated epigenetic modification has a crucial role in the pathology of metabolic dysfunction-associated fatty liver disease.
7. 1. Medicine
   2. Immunology and Inflammation

   C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

   Toru Tanaka, Naoto Sasaki ... Yoshiyuki Rikitake
8. 1. Evolutionary Biology
   2. Medicine

   The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesis

   Rion Brattig-Correia, Joana M Almeida ... Paulo Navarro-Costa

   An interdisciplinary research platform reveals that the transcriptional identity of metazoan male germ cells is built around a small network of deeply conserved gene interactions with an overarching functional impact.
9. 1. Medicine
   2. Neuroscience

   NE contribution to rebooting unconsciousness caused by midazolam

   LeYuan Gu, WeiHui Shao ... HongHai Zhang
10. 1. Medicine

    Evaluation of Gremlin-1 as a therapeutic target in metabolic dysfunction-associated steatohepatitis

    Paul Horn, Jenny Norlin ... Philip N Newsome

    Antibody-mediated neutralisation of Gremlin-1 was ineffective in treating fibrosis in metabolic dysfunction-associated steatohepatitits, likely due to low hepatic expression in a subset of myofibroblasts and redundant Gremlin-1 signalling.