Medicine

Latest articles

1. 1. Medicine
   2. Computational and Systems Biology

   Calibration and validation strategy for electromechanical cardiac digital twins

   Zhinuo Jenny Wang, Maxx Holmes ... Blanca Rodriguez
2. 1. Medicine

   The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming

   Zachary W Grimmett, Rongli Zhang ... Jonathan S Stamler
3. 1. Medicine
   2. Immunology and Inflammation

   C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

   Toru Tanaka, Naoto Sasaki ... Yoshiyuki Rikitake
4. 1. Medicine
   2. Neuroscience

   Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2

   Joanna Kosinska, Julian C Assmann ... Markus Schwaninger

   The therapeutic effect of dimethyl fumarate in experimental autoimmune encephalomyelitis depends on the diet of mice and is mediated by the G protein-coupled receptor HCAR2 in neutrophils.
5. 1. Cancer Biology
   2. Medicine

   Molecular feature-based classification of retroperitoneal liposarcoma: a prospective cohort study

   Mengmeng Xiao, Xiangji Li ... Li Min

   Identification of two molecularly distinct retroperitoneal liposarcoma subtypes, stratifiable via LEP and PTTG1 biomarkers, enables prognosis prediction and informs precision surgical strategies to improve clinical outcomes.
6. 1. Medicine

   Gamma Knife Stereotactic radiotherapy combined with tislelizumab as later-line therapy in hpMMR/MSS/MSI-L metastatic colorectal cancer: A Phase II Trial Analysis

   Yiran Zhang, Hanyang Guan ... Jinghua Pan
7. 1. Cell Biology
   2. Medicine

   Endometriosis is not the endometrium: Reviewing the over-representation of eutopic endometrium in endometriosis research

   Kate Gunther, Teagan Fisher ... Caroline Elizabeth Ford

   Nearly half of sequencing data labeled as endometriosis lacks true disease representation, highlighting the urgent need for more diverse and accurate tissue sampling to advance research in this underrepresented field.
8. 1. Medicine
   2. Neuroscience

   mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

   Philip Stavrides, Chris N Goulbourne ... Dun-Sheng Yang

   ALP alterations in Q175 brains are late-onset, mild, existing at the later phases of the pathway, and stimulating autophagy at early disease progression enhances mHTT clearance to ameliorate HD pathology.
9. 1. Medicine

   Efficacy and safety of neoadjuvant stereotactic body radiation therapy plus dalpiciclib and exemestane for hormone receptor-positive, HER2-negative breast cancer: A prospective pilot study

   Yu Zhang, Shuo Cao ... Caigang Liu
10. 1. Cell Biology
    2. Medicine

    AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism

    Zongwang Zhang, Lixia Zheng ... Jing-Wei Xiong

    AARS2 safeguards cardiomyocytes against ischemic injury by modulating PKM2-driven energy metabolism, revealing the AARS2-PKM2 axis as a previously unrecognized cardioprotective pathway in myocardial infarction.