Human Biology and Medicine

Human Biology and Medicine

eLife publishes research in clinical and translational research, human genetics, cancer, diabetes and developmental disorders. Learn more about what we publish and sign up for the latest research.
Illustration by Davide Bonazzi

Latest articles

    1. Cell Biology
    2. Human Biology and Medicine

    Endothelial-specific FoxO1 depletion prevents obesity-related disorders by increasing vascular metabolism and growth

    Martina Rudnicki et al.
    Stimulation of endothelial glucose metabolism and vascular growth by genetic depletion of endothelial Foxo1 improves the whole-body response to a high-fat diet, by preserving adipose tissue functions and glucose homeostasis.
    1. Human Biology and Medicine
    2. Neuroscience

    Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease

    Xunde Xian et al.
    Lowering endosomal pH through inhibition of sodium-hydrogen exchanger 6 corrects the ApoE4-induced Reelin resistance and restores neuronal glutamate receptor trafficking.
    1. Human Biology and Medicine
    2. Neuroscience

    Characterization of small fiber pathology in a mouse model of Fabry disease

    Lukas Hofmann et al.
    Globotriaosylcermide directly impacts neuronal integrity and ion channel function as potential mechanism underlying small fiber pathology in Fabry disease.
    1. Cell Biology
    2. Human Biology and Medicine

    Ryanodine receptor dispersion disrupts Ca2+ release in failing cardiac myocytes

    Terje R Kolstad et al.
    Experimental and mathematical modeling approaches identify a novel mechanism of heart failure, linking disrupted calcium homeostasis and impaired contractility of cardiacmyocytes to nanoscale reorganization of calcium release channels.
    1. Human Biology and Medicine

    Increase in clinically recorded type 2 diabetes after colectomy

    Anders B Jensen et al.
    This nationwide register-based study of diabetes risk after colectomy suggests that the left colon contributes to maintenance of glucose homeostasis.
    1. Human Biology and Medicine
    2. Neuroscience

    Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor

    Katrin H Preller et al.
    LSD induces a pattern of changed global brain connectivity characterized by hypo-connectivity in associative areas and hyper-connectivity across sensory and somatomotor areas that is dependent on the serotonin 2A receptor.
    1. Human Biology and Medicine
    2. Neuroscience

    Acute perturbation of Pet1-neuron activity in neonatal mice impairs cardiorespiratory homeostatic recovery

    Ryan T Dosumu-Johnson et al.
    Pet1 neurons actively maintain cardiorespiratory tone and dynamic range in mouse neonates and critically support the recovery response to apneas, informing brain findings in the sudden infant death syndrome.
    1. Human Biology and Medicine
    2. Neuroscience

    Autoresuscitation: The central role of serotonin

    Gary C Mouradian, Matthew R Hodges
    The neurotransmitter serotonin helps to co-ordinate the respiratory and cardiovascular responses of newborns to oxygen deprivation.
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    1. Human Biology and Medicine
    2. Neuroscience

    Insulin regulates POMC neuronal plasticity to control glucose metabolism

    Garron T Dodd et al.
    Feeding and fasting associated alterations in proopiomelanocortin neuronal responses to insulin coordinate glucose metabolism.

Senior editors

  1. Harry Dietz
    Harry Dietz
    Howard Hughes Medical Institute and Institute of Genetic Medicine, Johns Hopkins University School of Medicine, United States
  2. Wendy S Garrett
    Wendy S Garrett
    Harvard T.H. Chan School of Public Health, United States
  3. Prabhat Jha
    Prabhat Jha
    Saint Michael's Hospital, Canada
  4. See more editors