Human Biology and Medicine

eLife publishes research in clinical and translational research, human genetics, cancer, diabetes and developmental disorders. Decisions are made by journal editors who are active researchers in human biology and medicine.

Latest articles

    1. Developmental Biology and Stem Cells
    2. Human Biology and Medicine

    Erythropoietin signaling regulates heme biosynthesis

    Jacky Chung et al
    EPO/JAK2/PKA signaling cascade via AKAP10 relocalization to the outer mitochondrial membrane results in the phosphorylation of the terminal heme synthesis enzyme ferrochelatase, which contributes to heme production in red cells.
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    1. Human Biology and Medicine

    Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes

    Lorenzo Alamo et al
    Mapping the locations of hypertrophic cardiomyopathy gene variants onto the three-dimensional structures of contractile proteins revealed that these disrupt protein interactions are critical for normal cardiac relaxation and efficient energy usage.
    Research Article
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    1. Human Biology and Medicine
    2. Neuroscience

    Rai1 frees mice from the repression of active wake behaviors by light

    Shanaz Diessler et al
    Halving dosage of the Smith-Magenis syndrome responsible gene Rai1 in the mouse greatly amplifies the direct, suppressing effects of light on active-wake behavior through increased activation of the ventral-subparaventricular zone.
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    1. Genes and Chromosomes
    2. Human Biology and Medicine

    Transcriptional networks specifying homeostatic and inflammatory programs of gene expression in human aortic endothelial cells

    Nicholas T Hogan et al
    An integrative genome-wide approach supports a direct and collaborative role of ETS and AP-1 transcription factors in maintaining endothelial cell-specific and anti-inflammatory gene expression programs.
    Research Article
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    1. Human Biology and Medicine
    2. Neuroscience

    mTORC1 in AGRP neurons integrates exteroceptive and interoceptive food-related cues in the modulation of adaptive energy expenditure in mice

    Luke K Burke et al
    AGRP neurons integrate environmental food-related cues with internal metabolic signals to modulate interscapular brown adipose tissue thermogenesis and energy expenditure, at least in part, via mTORC1 signalling.
    Research Article
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    1. Human Biology and Medicine
    2. Neuroscience

    Humans treat unreliable filled-in percepts as more real than veridical ones

    Benedikt V Ehinger et al
    In a forced decision between two identical percepts, subjects preferentially rely on inferred internally generated over veridically seen percepts.
    Research Article
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    1. Cell Biology
    2. Human Biology and Medicine

    Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

    Nuno Rocha et al
    Specific human mitofusin 2 mutations induce selective upper body obesity with suppressed leptin expression and severe adipose mitochondrial dysfunction.
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    1. Genes and Chromosomes
    2. Human Biology and Medicine

    Synthetically modified guide RNA and donor DNA are a versatile platform for CRISPR-Cas9 engineering

    Kunwoo Lee et al
    The guide RNA and donor DNA of the CRISPR/Cas system tolerate large chemical modifications and can be engineered for enhanced delivery and gene editing.
    Short Report
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    1. Human Biology and Medicine

    Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro

    Giovanni Stefano Ugolini et al
    Human cardiac fibroblasts regulate their cellular responses according to the combination of multiple environmental stimuli namely oxygen changes and mechanical signals.
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    1. Cell Biology
    2. Human Biology and Medicine

    Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis

    Yu A An et al
    Gain- and loss-of-function studies highlight the important role for angiopoietin-2 to maintain adipose tissue health during metabolic challenges.
    Research Article Updated
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