Medicine

Medicine

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Latest articles

    1. Medicine

    Magnesium isoglycyrrhizinate alleviates alcohol-associated liver disease through targeting HSD11B1

    Lu Xiao, Lu Li ... Jia Xiao
    MgIG directly targets HSD11B1 to alleviate alcohol-associated liver disease by suppressing the HSD11B1–SREBP2–IDI1 pathway, thereby reducing hepatic steatosis, inflammation, and apoptosis.
    1. Medicine
    2. Immunology and Inflammation

    TLR4 signaling drives tissue inflammation, Claudin-5 internalization, and vascular barrier breakdown in a mouse model of neonatal meningitis

    Philip V Seegren, Amir Rattner ... Jeremy Nathans
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Medicine

    Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury

    Yaying Zhu, Chengxiang Deng ... Zhao Shan
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Incomplete
    1. Medicine

    Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

    Tobias Kaufmann, Pål Marius Bjørnstad ... Timothy Hughes
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Medicine

    Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study

    Carolyne Jie Huang, Samuel Pawel ... Rachel Heyard
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Chromosomes and Gene Expression
    2. Medicine

    Gene dosage imbalance disrupts systemic metabolism in the Dp16 Down syndrome mouse model

    Fangluo Chen, Muzna Saqib ... G William Wong
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Compelling
    1. Medicine
    2. Computational and Systems Biology

    Calibration and validation strategy for electromechanical cardiac digital twins

    Zhinuo Jenny Wang, Maxx Holmes ... Blanca Rodriguez
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Genetics and Genomics
    2. Medicine

    Translational reading frame determines the pathogenicity of C-terminal frameshift deletions in MeCP2: an alternative therapeutic approach

    Jacky Guy, Elena Hein ... Adrian Bird
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Medicine
    2. Neuroscience

    Synthetic torpor in the rat protects the heart from ischaemia-reperfusion injury

    Megan Elley, Ludovico Taddei ... Michael Ambler
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Genetics and Genomics
    2. Medicine

    Single-cell transcriptome-wide Mendelian randomization and colocalization analyses reveal immune-cell-specific mechanisms and actionable drug targets in prostate cancer

    Yanggang Hong, Yi Wang ... Jiajun Li
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
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Highlights

    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease
    3. Medicine

    Focus Issue: Trained Immunity

    Edited by Satyajit Rath et al.
    1. Genetics and Genomics
    2. Medicine

    Responding to peer reviewers

    Eric Kalkhoven, Manon Kluijtmans
    1. Medicine
    2. Structural Biology and Molecular Biophysics

    Medical Imaging: MRI sets its sights on collagen

    Fritz Schick

Senior editors

  1. Balram Bhargava
    Indian Council of Medical Research, India
  2. Christopher L-H Huang
    University of Cambridge, United Kingdom
  3. Joshua T Schiffer
    Fred Hutchinson Cancer Research Center, United States
  4. See more editors