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Latest articles

    1. Immunology and Inflammation
    2. Medicine

    C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in mice

    Toru Tanaka, Naoto Sasaki ... Yoshiyuki Rikitake
    CCR4 expression in Tregs is critical for limiting proinflammatory Th1 cell-mediated immune responses and atherosclerosis by maintaining the suppressive and migratory functions of Tregs.
    1. Medicine

    Serum, Cell-Free, HPV-Human DNA Junction Detection and HPV Typing for Predicting and Monitoring Cervical Cancer Recurrence

    Anne Van Arsdale, Olga Mescheryakova ... Jack Lenz
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Cancer Biology
    2. Medicine

    Gamma Knife stereotactic radiotherapy combined with tislelizumab as later-line therapy in pMMR/MSS/MSI-L metastatic colorectal cancer: a phase II trial analysis

    Yiran Zhang, Hanyang Guan ... Jinghua Pan
    Patients with microsatellite stable/low microsatellite instability mismatch repair-proficient metastatic colorectal cancer may be sensitive to tislelizumab treatment after receiving Gamma Knife stereotactic radiotherapy.
    1. Medicine

    Addressing cultural and knowledge barriers to enable preclinical sex inclusive research

    Brianna N Gaskill, Benjamin Phillips ... Natasha A Karp
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Medicine

    Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging

    Duilio M Potenza, Xin Cheng ... Xiu-Fen Ming
    Revised
    Reviewed Preprint v2
    Updated
    • Fundamental
    • Convincing
    1. Medicine

    Aging: Multiple roles for a mitochondrial enzyme

    Xicong Tang, Hongyu Qiu
    The enzyme arginase-II has an important role in cardiac aging, and blocking it could help hearts stay young longer.
    Version of Record
    Insight
    1. Medicine

    Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans

    Yifan Xiang, Vineeta Tanwar ... Pankaj Kapahi
    Revised
    Reviewed Preprint v3
    Updated
    • Important
    • Solid
    1. Medicine

    The denitrosylase SCoR2 controls cardioprotective metabolic reprogramming

    Zachary W Grimmett, Rongli Zhang ... Jonathan S Stamler
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Compelling
    1. Medicine
    2. Computational and Systems Biology

    Calibration and validation strategy for electromechanical cardiac digital twins

    Zhinuo Jenny Wang, Maxx Holmes ... Blanca Rodriguez
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete
    1. Medicine
    2. Neuroscience

    Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR2

    Joanna Kosinska, Julian C Assmann ... Markus Schwaninger
    The therapeutic effect of dimethyl fumarate in experimental autoimmune encephalomyelitis depends on the diet of mice and is mediated by the G protein-coupled receptor HCAR2 in neutrophils.
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Highlights

    1. Medicine

    Enzymes and cardiac aging

    Xicong Tang, Hongyu Qiu
    1. Epidemiology and Global Health
    2. Medicine
    3. Microbiology and Infectious Disease

    Explore the latest COVID-19 research

    Edited by Diane M Harper et al.
    1. Medicine

    Meet our new Senior Editors in Medicine

Senior editors

  1. Christopher L-H Huang
    University of Cambridge, United Kingdom
  2. Caigang Liu
    Shengjing Hospital of China Medical University, China
  3. Dolores Shoback
    University of California, San Francisco, United States
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