Immunology

eLife publishes research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Decisions are made by journal editors who are active researchers in the field of immunology.

Latest articles

    1. Biophysics and Structural Biology
    2. Immunology

    Fluorescence Lifetime Imaging Microscopy reveals rerouting of SNARE trafficking driving dendritic cell activation

    Daniëlle Rianne José Verboogen et al
    A novel microscopy-based assay shows that dendritic cells encountering pathogenic stimuli form increased complexes of specific SNARE proteins, driving release of large amounts of inflammatory cytokines.
    Research Article Updated
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    1. Biophysics and Structural Biology
    2. Immunology

    Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity

    Michael Saitakis et al
    Multiple functions of human T lymphocytes are shown to be potentiated within a wide range of physiological cell and tissue rigidities.
    Research Article
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    1. Immunology

    Functionally diverse human T cells recognize non-microbial antigens presented by MR1

    Marco Lepore et al
    MR1T cells are human polyclonal T cells endowed with diverse effector functions in response to endogenous antigens presented by MHC-class 1-related molecule, MR1.
    Research Article Updated
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    1. Immunology

    Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation

    Yong Miao et al
    Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.
    Research Article Updated
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    1. Immunology

    The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition

    Fu-Lien Hsieh, Matthew K Higgins
    The structure of a human antibody in which the variable loops position a human protein LAIR1 for antigen recognition, reveals a novel and indirect mode of antibody function.
    Short Report Updated
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    1. Immunology

    IL17 factors are early regulators in the gut epithelium during inflammatory response to Vibrio in the sea urchin larva

    Katherine M Buckley et al
    Expression of two highly regulated subfamilies of the complex multigene family encoding IL-17 cytokines in the purple sea urchin are sequentially activated in a larval gut-associated inflammation model and modulate downstream gene expression in the gut epithelium.
    Research Article Updated
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    1. Cell Biology
    2. Immunology

    Diverse stimuli engage different neutrophil extracellular trap pathways

    Elaine F Kenny et al
    1. Immunology

    Cytokines: A gut response

    Matthew L Nicotra
    Unexpected findings from the immune system of sea urchin larvae potentially provide insights into immune signaling in ancestral lifeforms.
    Insight
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    1. Cell Biology
    2. Immunology

    TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway

    Andreas Neerincx et al
    The recently discovered peptide editor TAPBPR binds to UDP-glucose:glycoprotein glucosyltransferase 1 to provide quality control in the antigen presentation pathway by facilitating the reglucosylation of the glycan on MHC class I molecules.
    Research Article Updated
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