Immunology

Immunology

eLife publishes research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Decisions are made by journal editors who are active researchers in the field of immunology.
Illustration by Davide Bonazzi

Latest articles

    1. Immunology

    Tuning of in vivo cognate B-T cell interactions by Intersectin 2 is required for effective anti-viral B cell immunity

    Marianne Burbage et al.
    Intersectin2 deficiency is associated with impaired humoral responses to viral infection and B-cell-intrisic defects in germinal centre formation, resulting from the reduced ability of intersectin2-KO B cells to establish cognate interactions with helper T cells.
    1. Immunology

    A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice

    Fei Tang et al.
    A novel population of hematopoietic cells unmasked by mTORC1 inactivation reveals a new mechanism of innate immune tolerance and a new consequence of defective hematopoiesis.
    1. Immunology

    Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection

    Sharon M Campbell et al.
    Macrophage dynamics are fundamentally different between two commonly used inbred mouse strains and differences in local resident cell expansion versus monocyte recruitment determine the outcome of tissue nematode infection.
    1. Cell Biology
    2. Immunology

    T-cell calcium dynamics visualized in a ratiometric tdTomato-GCaMP6f transgenic reporter mouse

    Tobias X Dong et al.
    Salsa6f is a novel, ratiometric genetically encoded Ca2+ indicator that combines the power of ratiometric chemical Ca2+ indicators with the ability, when expressed transgenically, to image cellular Ca2+ signals amid complex tissue environments in vivo.
    1. Immunology
    2. Cell Biology

    Calcium-mediated shaping of naive CD4 T-cell phenotype and function

    Vincent Guichard et al.
    Calcium-calcineurin signaling cascade drives the acquisition of both the phenotype of the most self-reactive naive CD4 T cells and their enhanced cell-intrinsic ability to commit into induced regulatory T cells upon activation.
    1. Cell Biology
    2. Immunology

    Intermittent Ca2+ signals mediated by Orai1 regulate basal T cell motility

    Tobias X Dong et al.
    Orai1 channels activate intermittently in motile T cells, generating calcium transients, detected by a novel genetically encoded indicator and inducing pauses that favor antigen scanning.
    1. Biophysics and Structural Biology
    2. Immunology

    Computationally-driven identification of antibody epitopes

    Casey K Hua et al.
    The combination of computational modeling and protein design can reveal key determinants of antibody‚Äďantigen binding and optimize small sets of antigen variants for efficient experimental localization of epitopes.
    1. Immunology
    2. Microbiology and Infectious Disease

    A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis

    Zhaowei Wang et al.
    A picorna-like virus promotes the accumulation of caspase-cleaved drosophila inhibitor of apoptosis 1 by inducing the degradation of NTAN1, a key N-end rule degradation pathway component, leading to apoptosis inhibition and viral replication enhancement.
    1. Immunology

    CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

    Xiaomei Yuan et al.
    Tissue-resident macrophages sense environmental cues and regulate adaptive immunity via an immune checkpoint molecule CRIg.

Senior editors

  1. Wendy S Garrett
    Wendy S Garrett
    Senior Editor
  2. Michel C Nussenzweig
    Michel C Nussenzweig
    Senior Editor
  3. Tadatsugu Taniguchi
    Tadatsugu Taniguchi
    Senior Editor
  4. See more editors