Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Bacterial Clearance: With a little help from T cells

   Troy Burtchett, Neal Hammer

   Specific host factors, such as immune cell activity, sex hormones and microbiota composition, influence the ability of Staphylococcus aureus bacteria to colonize the gut of mice.
2. 1. Immunology and Inflammation
   2. Neuroscience

   Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive decline

   Jeremy M Shea, Saul A Villeda

   During aging, microglia progress through intermediate cellular states, including stress response and translation upregulation states, that modulate subsequent activation and impact cognitive decline.
3. 1. Immunology and Inflammation

   Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice

   Mohsen Khosravi-Maharlooei, Andrea Vecchione ... Megan Sykes

   Functional analyses identify Tfh-like and Tph-like CD4⁺ T cells as drivers of a spontaneous autoimmune syndrome characterized by autoreactive B cells in human immune system mice.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7

   Li Tian, Zongzheng Zhao ... Zhaolong Li
5. 1. Immunology and Inflammation
   2. Evolutionary Biology

   Evolutionary and functional analyses reveal a role for the RHIM in tuning RIPK3 activity across vertebrates

   Elizabeth J Fay, Kolya Isterabadi ... Matthew D Daugherty
6. 1. Immunology and Inflammation

   A host enzyme reduces metabolic dysfunction-associated steatotic liver disease (MASLD) by inactivating intestinal lipopolysaccharide

   Zhiyan Wang, Nore Ojogun ... Mingfang Lu

   A MASLD mouse model reveals that gut-derived Gram-negative bacterial lipopolysaccharides promote hepatic lipid accumulation and acyloxyacyl hydrolase, a host lipase that degrades and inactivates lipopolysaccharides and mitigates MASLD.
7. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

   Malika Hale, Kennidy K Takehara ... Marion Pepper

   Immune memory B cells in people with cystic fibrosis contain bacteria-specific sequences that could be used to make new treatments for life-threatening infections.
8. 1. Cell Biology
   2. Immunology and Inflammation

   RAS–p110α signalling in macrophages is required for effective inflammatory response and resolution of inflammation

   Alejandro Rosell, Agata Adelajda Krygowska ... Esther Castellano Sanchez

   Disruption of RAS–p110α signalling in macrophages impairs both the initiation and resolution of inflammatory responses, revealing a critical regulatory role in immune function and inflammation control.
9. 1. Immunology and Inflammation
   2. Computational and Systems Biology

   Deconstructing Complexity: A Computational Topology Approach to Trajectory Inference in the Human Thymus with tviblindi

   Jan Stuchly, David Novak ... Tomas Kalina
10. 1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Distinct adaptation and epidemiological success of different genotypes within Salmonella enterica serovar Dublin

    Cheryll M Sia, Rebecca L Ambrose ... Danielle J Ingle