Browse our latest Immunology and Inflammation articles

Transcriptomic and bionergetic analysis shows the importance of HIF-1α activation in enabling tissue-resident alveolar macrophages to perform glycolytic metabolism, which prevents their death and attenuates influenza A virus-induced acute lung injury.

Yeast surface-displayed libraries, when coupled with pooled oligonucleotide synthesis and next-generation sequencing, can be used as a platform to assess binding of whole viral proteomes to class II major histocompatibility complex proteins.

An improved 'plug-and-play' reversed FluoroSpot assay is described and validated that allows the simultaneous assessment of antibody cross-reactivity at the single-cell level against up to four variants of a polymorphic antigen of interest.

A model-based approach for modelling the immune control of viral dynamics is applied to quantify the effect of several SARS-CoV-2 vaccine platforms and to define mechanistic correlates of protection.

Pathological TNF-α-producing B cells are involved in the pathological process of polycystic ovary syndrome, and metformin inhibits mTOR phosphorylation, affects metabolic reprogramming, and further inhibits TNF-α expression in pathological B cells.

Internalization of apoptotic SARS-CoV-2 infected cells leads to proinflammatory macrophage activation and reduction in macrophage capacity to perform further efferocytosis.

Macrophages absorbing cells infected with viable SARS-CoV-2 particles fail to transition into an anti-inflammatory state, potentially contributing to a damaging immune reaction linked to severe forms of COVID-19.

A honeycomb-lattice assembly within the skin and mucosa protects us from invading pathogens.

RUNX2 plays an important role in human NK cell biology by driving differentiation, inhibiting cytokine production, and inducing a tissue-resident phenotype, which has implications for improving NK cell therapy for cancer patients.

Glycans are remodeled by HIV and are determinants of CD4+ T cell susceptibility to HIV infection.