Immunology and Inflammation

Latest articles

1. 1. Cell Biology
   2. Immunology and Inflammation

   Arpin deficiency increases actomyosin contractility and vascular permeability

   Armando Montoya-Garcia, Idaira M Guerrero-Fonseca ... Michael Schnoor

   Arpin regulates actomyosin contractility and endothelial barrier integrity by controlling the activity of the kinases ROCK1 and ZIPK, but not Arp2/3.
2. 1. Immunology and Inflammation

   The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice

   Alexandra a Aybar-Torres, Lennon A Saldarriaga ... Lei Jin

   The common human HAQ,AQ alleles suppress STING1 gain-of-function mutation-induced chronic STING1 inflammation in mice.
3. 1. Immunology and Inflammation

   The Extra-Islet Pancreas Supports Autoimmunity in Human Type 1 Diabetes

   GL Barlow, CM Schürch ... PL Bollyky
4. 1. Immunology and Inflammation

   The bacterial quorum sensing signal 2’-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection

   Arijit Chakraborty, Arunava Bandyopadhaya ... Laurence G Rahme

   The Pseudomonas aeruginosa secreted signaling molecule 2'-aminoacetophenone modulates cellular immunometabolism to promote persistence in infected tissues.
5. 1. Immunology and Inflammation

   Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice

   Alessandra Machado Araujo, Joseph D Dekker ... Haley O Tucker

   Single-cell RNA-seq data and transgenic models revealed B-plasmacytoid dendritic cells (B-pDCs) represent a phenotypically and functionally distinct common lymphoid progenitor-derived pDC lineage specialized in T cell activation and previously not described in mice.
6. 1. Immunology and Inflammation

   Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

   Jiansen Lu, Jiahuan Zhang ... Xiao Yu

   Vangl2 induced by inflammation recruits ubiquitin ligase PDLIM2 and increases K63-linked ubiquitination on p65, which promotes the recognition of p65 by cargo receptor NDP52 and the autophagic degradation of p65.
7. 1. Cell Biology
   2. Immunology and Inflammation

   S-acylation of NLRP3 provides a nigericin sensitive gating mechanism that controls access to the Golgi

   Daniel M Williams, Andrew A Peden

   Recruitment of NLRP3 to the Golgi is controlled by the reversible addition of a lipid anchor adjacent to the polybasic region.
8. 1. Medicine
   2. Immunology and Inflammation

   Preeclampsia-specific immune cell network in placenta revealed by Cytometry by time of flight and single-cell RNA-seq

   Haiyi Fei, Xiaowen Lu ... Lingling Jiang
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Chemokine expression profile of an innate granuloma

   Megan E Amason, Cole J Beatty ... Edward A Miao
10. 1. Immunology and Inflammation

    Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis dependent functional plasticity

    Donal J Cox, Sarah A Connolly ... Joseph Keane