Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Dichloroacetate reverses sepsis-induced hepatic metabolic dysfunction

   Rabina Mainali et al.

   Integrative multi-omics reveals global dysregulation in hepatic metabolism during prolonged sepsis.
2. 1. Biochemistry and Chemical Biology
   2. Immunology and Inflammation

   Integration of IL-2 and IL-4 signals coordinates divergent regulatory T cell responses and drives therapeutic efficacy

   Julie Y Zhou et al.

   Simultaneous cytokine signaling results in unexpected transcription factor changes that fuel a cellular response divergent from the sum of each cytokine alone.
3. 1. Cancer Biology
   2. Immunology and Inflammation

   Human primed ILCPs support endothelial activation through NF-κB signaling

   Giulia Vanoni et al.

   Circulating human primed innate lymphoid cell precursors have the potential to functionally induce adhesion molecules' expression in endothelial cells and possibly support the immune cells' infiltration into the tumor site.
4. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Virus infection of the CNS disrupts the immune-neural-synaptic axis via induction of pleiotropic gene regulation of host responses

   Olga A Maximova et al.

   Virus infection of the central nervous system disrupts the homeostasis of the immune-neural-synaptic axis via induction of pleiotropic genes with an unintended off-target negative impact on the neurotransmission.
5. 1. Immunology and Inflammation
   2. Medicine

   Perinatal granulopoiesis and risk of pediatric asthma

   Benjamin A Turturice et al.

   Perinatal granulopoiesis and cord blood serum PGLYRP-1, a specific granule protein, are altered prior to onset of childhood asthma and provide potential targets for early identification of at-risk populations.
6. 1. Immunology and Inflammation

   The kinase PDK1 is critical for promoting T follicular helper cell differentiation

   Zhen Sun et al.

   PDK1 serves as a critical role for intrinsically promoting T follicular helper cell differentiation and effector functions via controlling expression level of TCF1.
7. 1. Immunology and Inflammation

   Cell-density independent increased lymphocyte production and loss rates post-autologous HSCT

   Mariona Baliu-Piqué et al.

   Altered lymphocyte dynamics after hematopoietic stem cell transplantation cannot solely be explained by low lymphocyte numbers.
8. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   A paucigranulocytic asthma host environment promotes the emergence of virulent influenza viral variants

   Katina D Hulme et al.

   Patients with paucigranulocytic asthma may be more susceptible to severe influenza and could potentially be source of new, more virulent, influenza virus variants.
9. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Development of antibody-dependent cell cytotoxicity function in HIV-1 antibodies

   Laura E Doepker et al.

   HIV-specific antibodies that mediate antibody-dependent cellular cytotoxicity vary in their paths to achieve function but commonly rely on mutations in multiple regions, including framework regions, to reach full potency.
10. 1. Immunology and Inflammation

    The clonal structure and dynamics of the human T cell response to an organic chemical hapten

    Tahel Ronel et al.

    Chronic exposure to a potent chemical contact sensitizer drives a self-limiting expansion of a polyclonal population of T cells recognizing a small number of dominant antigens.