Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   IL-33 promotes innate lymphoid cell-dependent IFN-γ production required for innate immunity to Toxoplasma gondii

   Joseph T Clark et al.

   Upon Toxoplasma gondii infection, IL-33 plays a critical role in driving early anti-parasite responses by innate lymphoid cells rendered responsive to its effects by infection.
2. 1. Cell Biology
   2. Immunology and Inflammation

   Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node

   Shannon M Walsh et al.

   Antigen-phosphorothioate DNA conjugation provides a vaccination strategy where stable barcodes facilitate the detection and quantification of antigen using single-cell RNA sequencing.
3. 1. Developmental Biology
   2. Immunology and Inflammation

   T cell self-reactivity during thymic development dictates the timing of positive selection

   Lydia K Lutes et al.

   Developing T cells whose TCRs have relatively low reactivity experience very brief TCR signaling events, experience delayed positive selection, and retaina preselection gene expression signature as they mature.
4. 1. Immunology and Inflammation

   NHR-49/PPAR-α and HLH-30/TFEB cooperate for C. elegans host defense via a flavin-containing monooxygenase

   Khursheed A Wani et al.
5. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   ImmunoCluster provides a computational framework for the nonspecialist to profile high-dimensional cytometry data

   James W Opzoomer et al.

   ImmunoCluster permits nonspecialist users to interrogate liquid and imaging mass, and flow cytometry datasets, resolving novel layers of cellular heterogeneity and insight, as well as producing publishable outputs and figures.
6. 1. Immunology and Inflammation

   Fate mapping analysis reveals a novel murine dermal migratory Langerhans-like cell population

   Jianpeng Sheng et al.

   Fate mapping analysis shows that not bona fide Langerhans cells but their ‘look-alikes’ dermal Langerhans cell-like cells migrate to the lymph nodes.
7. 1. Immunology and Inflammation

   Skin Immunity: A new player in the dermis

   Gyohei Egawa, Kenji Kabashima

   Langerhans-like cells located in the dermis can travel to lymph nodes where they modulate immune responses.
8. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   CRISPR-based functional genomics in human dendritic cells

   Marco Jost et al.

   A CRISPR-based method enables targeted knockouts and genetic screens in human dendritic cells.
9. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses

   Stephan Wilmes et al.

   IL-27 exerts differential activation of STAT1 and STAT3 via IL-27Ra and GP130, respectively, leading to a kinetic decoupling of its gene expression program, which contributes to tune its immuno-modulatory activities.
10. 1. Immunology and Inflammation

    CD8⁺ T cell self-tolerance permits responsiveness but limits tissue damage

    Emily N Truckenbrod et al.