Immunology and Inflammation

Latest articles

1. 1. Immunology and Inflammation

   Human thymopoiesis produces polyspecific CD8⁺ α/β T cells responding to multiple viral antigens

   Valentin Quiniou, Pierre Barennes ... David Klatzmann

   The thymic selection of the human T-cell receptor repertoire releases polyspecific receptors with the ability to recognize and respond to peptides from unrelated viruses.
2. 1. Immunology and Inflammation

   A lncRNA identifies Irf8 enhancer element in negative feedback control of dendritic cell differentiation

   Huaming Xu, Zhijian Li ... Martin Zenke

   A novel lncRNA marks the Irf8 downstream enhancer that is crucial for differentiation of plasmacytoid dendritic cells (pDC) and classical dendritic cells type 1 (cDC1) and confers feedback inhibition of Irf8 transcription.
3. 1. Immunology and Inflammation

   Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling

   Xing Feng, Ruifeng Sun ... Joao Pedro Pereira

   Acute lymphoblastic and myeloblastic leukemias activate lymphotoxin beta receptor in mesenchymal stem cells in the bone marrow to turn off interleukin-7 production and lymphopoiesis and gain competitive advantage.
4. 1. Immunology and Inflammation

   Characterisation of the immune repertoire of a humanised transgenic mouse through immunophenotyping and high-throughput sequencing

   Eve Richardson, Špela Binter ... Simon J Watson
5. 1. Immunology and Inflammation
   2. Microbiology and Infectious Disease

   Antigenic mapping and functional characterization of human new world hantavirus neutralizing antibodies

   Taylor B Engdahl, Elad Binshtein ... James E Crowe Jr.
6. 1. Immunology and Inflammation

   PTPN22 R620W gene editing in T cells enhances low avidity TCR responses

   Warren Anderson, Fariba Barahmand-pour-Whitman ... David J Rawlings
7. 1. Cell Biology
   2. Immunology and Inflammation

   HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

   Sara Scinicariello, Adrian Soderholm ... Gijs A Versteeg

   HUWE1 indirectly mediates the return to cellular homeostasis after pro-inflammatory responses, which it does by controling the stability of the immune suppressor tristetraprolin.
8. 1. Computational and Systems Biology
   2. Immunology and Inflammation

   Short-range interactions between fibrocytes and CD8⁺ T cells in COPD bronchial inflammatory response

   Edmée Eyraud, Elise Maurat ... Isabelle Dupin
9. 1. Epidemiology and Global Health
   2. Immunology and Inflammation

   Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC)

   Zaki A Sherif, Christian R Gomez ... RECOVER Mechanistic Pathway Task Force

   PASC (post-acute sequelae of SARS-CoV-2 infection) is an enduring and debilitating illness caused by a persistent virus that promotes inflammation, coagulation, and autoimmunity complications in millions of patients initially diagnosed with COVID-19, but with no known standardized treatment regimen.
10. 1. Immunology and Inflammation

    Involvement of ILC1-like innate lymphocytes in human autoimmunity, lessons from alopecia areata

    Rimma Laufer Britva, Aviad Keren ... Amos Gilhar

    Innate lymphoid cells type 1 suffice to induce hallmarks of alopecia areata phenotype in organ-cultured human scalp hair follicles ex vivo and in human scalp skin xenotransplants in vivo, suggesting that these cells play a role in early AA pathogenesis.