Harriet Hunter, Dana de Gracia Hahn ... Jake P Mann
Animal studies of fatty liver disease over-estimate the benefit of drugs due to publication bias and are confounded by off-target weight loss, illustrating the challenge of successful translational across species.
Boran Hao, Shahabeddin Sotudian ... Ioannis Ch Paschalidis
Using data for 2566 COVID-19 patients from five hospitals, models are developed to predict for each patient hospitalization and critical care needs, based on demographics, comorbidities, medications, and laboratory findings.
Danae E Zamboulis, Chavaunne T Thorpe ... Peter D Clegg
Phase-specific mechanical and proteomic analyses reveal how tendon responds to its mechanical environment during postnatal development to meet functional requirements.
Pedrum Mohammadi-Shemirani, Michael Chong ... Guillaume Paré
Long-term increased testosterone improved body composition and bone density, but lowered HDL and raised risks of hypertension, androgenic alopecia, prostate cancer, and spinal stenosis in males.
Mitsuru Shinohara, Takahisa Kanekiyo ... Guojun Bu
Translational evidence indicates APOE2 benefits longevity independent of its protective effects on Alzheimer’s disease, which preserved activity and the metabolism of apoE protein and associated-lipids would be key to understanding.
Hypoplastic left heart syndrome is reflected by reduced proliferative capacity of patient iPSC-derived cardiomyocytes and requires the activity of LRP2/APOB proteins, likely in conjunction with SHH and WNT signaling pathways.
Recording the neural activity of cells in the brain of patients with Parkinson's disease challenges long-standing assumptions about how this disease manifests at the cellular level.
Kristoffer B Hansen, Christian Staehr ... Ebbe Boedtkjer
HCO3–-sensitive regulation of endothelium-dependent vasorelaxation by receptor-type tyrosine-protein phosphatase RPTPγ provides a novel mechanism for acid-base-mediated coordination of cerebrovascular perfusion during increased local metabolism and for protection against ischemia.
Lynda S Ostedgaard, Margaret P Price ... Michael J Welsh
Submucosal glands are critical for two key respiratory host defenses, bactericidal activity and mucociliary transport, in an animal model that has lungs like humans.
