Enterovirus D68, a pathogen associated with a rare child paralysis disease, depends on the cellular protein SIRT-1 for release of virus, indicating that SIRT-1 may be an important therapeutic target.
σ28-Dependent sRNAs fine-tune flagella synthesis, with one sRNA connecting synthesis with metabolism and two sRNAs with opposing effects connecting synthesis with ribosomal protein production through unique binding within coding sequences.
Louiza S Velentzis, Megan A Smith ... Karen Canfell
Results from this modelled analysis indicate that short-term delays in HPV vaccination of adolescents are unlikely to have substantial long-term effects on HPV-related cancers, provided catch-up of missed vaccine doses can be implemented.
Abhishek Jamwal, Cristina F Constantin ... Matthew K Higgins
The most effective growth-neutralising antibodies which target the PfRH5 protein from a malaria parasite function by preventing the parasite from binding to basigin-containing membrane protein complexes on human erythrocytes.
A new mass spectrometry-based method to identify and quantify changes in a subcellular local protein environment shows the impact of deletion of a kinase the human malaria parasites export into the host cell.
Joseph L Basalla, Claudia A Mak ... Anthony G Vecchiarelli
Carbon-fixing organelles, called carboxysomes, link to their spatial organization system in the bacterial cell by a hexameric protein that forms pH-dependent condensates via a nuanced multidomain mechanism.
A newly established reversible model of membrane departitioning and repartitioning in bacteria uncovers the role of a cell wall synthase in regulating membrane partitioning.
