Browse our latest Microbiology and Infectious Disease articles

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    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    An optimal regulation of fluxes dictates microbial growth in and out of steady state

    Griffin Chure, Jonas Cremer
    Microbial cells optimally structure their proteomes in order to mutually maximize metabolism and translation, as established by an extensive comparison between data and a low-dimensional model of cellular physiology.
    1. Microbiology and Infectious Disease

    Integration host factor regulates colonization factors in the bee gut symbiont Frischella perrara

    Konstantin Schmidt, Gonçalo Santos-Matos ... Philipp Engel
    Genes for adhesion, interbacterial competition, and secondary metabolite production are important colonization factors of the honey bee gut symbiont Frischella perrara and are regulated by the conserved histone-like DNA-binding protein integration host factor.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Viruses: How avian influenza viruses spill over to mammals

    Arturo Barbachano-Guerrero, Daniel R Perez, Sara L Sawyer
    The H3N2 canine influenza virus – which originally came from birds – is evolving to become more transmissible between dogs.
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    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Competition between lysogenic and sensitive bacteria is determined by the fitness costs of the different emerging phage-resistance strategies

    Olaya Rendueles, Jorge AM de Sousa, Eduardo PC Rocha
    The emergence and evolution of different phage-resistance strategies during coevolution between a phage-sensitive strain and a polylysogenic competitor depend on the amount of phage pressure, the fitness costs of resistance, and how these may change at different time scales.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

    Ean Spielvogel, Sook-Kyung Lee ... Ronald Swanstrom
    New HIV-1 protease inhibitor designs result in more potent inhibitors with high genetic barriers to resistance and the ability to lead virus evolution down less fit pathways when resistance occurs.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Rescue of Escherichia coli auxotrophy by de novo small proteins

    Arianne M Babina, Serhiy Surkov ... Michael Knopp
    De novo-generated small proteins can cause deattenuation of an amino acid biosynthetic operon by direct protein–RNA interactions.
    1. Developmental Biology
    2. Microbiology and Infectious Disease

    Hypoxia-induced tracheal elasticity in vector beetle facilitates the loading of pinewood nematode

    Xuan Tang, Jiao Zhou ... Jianghua Sun
    An insect-transmissible plant pathogen, Bursaphelenchus xylophilus, uniquely excavates hypoxia to increase vector capacity via Muc91C-enhanced elasticity of tracheal tubes.
    1. Microbiology and Infectious Disease

    Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment

    Abdirahman I Abdi, Fiona Achcar ... Matthias Marti
    We investigate how parasites adapt to environmental changes in the context of changing transmission patterns, for example by increasing investment in transmission stages at low endemicity such as elimination settings.
    1. Microbiology and Infectious Disease

    Promoting Fc-Fc interactions between anti-capsular antibodies provides strong immune protection against Streptococcus pneumoniae

    Leire Aguinagalde Salazar, Maurits A den Boer ... Suzan HM Rooijakkers
    Fc engineering of monoclonal antibodies strongly improves immune clearance of pneumococcus.
    1. Microbiology and Infectious Disease

    Viral Replication: Learning more about hepatitis E virus

    Altaira D Dearborn, Ashish Kumar, Joseph Marcotrigiano
    A domain in the ORF1 polyprotein of the hepatitis E virus that was previously thought to be a protease is actually a zinc-binding domain.
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