Peter H Chipman, Chi Chung Alan Fung ... Yukiko Goda
Electrophysiology experiments with genetic and pharmacological manipulations identify a role for astrocyte GluN2C NMDA receptors in maintaining the broad range of presynaptic strengths, which is suggested by numerical simulations to enhance the expression of synaptic plasticity.
Using single nucleus RNA sequencing, a complete catalogue of cell types was determined for the mouse iris, and this information was used as a starting point to define the effects of pupil dilation on gene expression and on nuclear morphology.
Leonhard Waschke, Thomas Donoghue ... Jonas Obleser
Waschke and colleagues demonstrate that aperiodic EEG activity not only captures subtle attention-related changes in brain signals but also tracks 1/f-like sensory input.
Domino K Schlegel, Srinivasagan Ramkumar ... Stephan CF Neuhauss
The retinoid-binding protein RLBP1 in the retinal pigment epithelium is crucially involved in cone photoreceptor visual pigment recycling and mimics the human eye disease with retinal lipid deposits when mutated.
Didac Vidal-Pineiro, Yunpeng Wang ... Anders Fjell
Longitudinal neuroimaging models reveal that cross-sectional indices of brain age do not significantly relate to ongoing brain change, that is, brain aging, but to lifelong, stable variations in brain structure emerging in early life.
The proposed techniques enable researchers to disentangle the statistical features of neural population responses, and rigorously quantify how these features carry information about stimuli and experimental variables.
Methods for screening hundreds of DNA sequences for enhancer activity have been extended for use in vivo, uncovering novel enhancer elements active in the early postnatal brain.
Hand somatotopy can be preserved in the primary somatosensory cortex of tetraplegic patients, despite the absence of sensorimotor function and periphery-brain communication, but deteriorates over years after injury.
