Browse our latest Structural Biology and Molecular Biophysics articles

p53 folding is critically dependent on zinc, and a synthetic metallochaperone rescues tumorigenic mutations that reduce p53's zinc affinity as well as thermodynamic stability.

Nucleosome binding by PRC2 threads H3K27 into its active site via an interaction network set in register by unmodified H3K36.

Structure of the Ca²⁺ channel Orai in an open conformation provides insights into the opening mechanism and the channel's role in regulating Ca²⁺ entry into immune and other non-excitable cells.

Temperature-sensitivity of archaebacterial potassium channel MthK is regulated by RCK domain via alteration of allosteric coupling.

Imaging sperm as they travel through the female reproductive tract has revealed new details about fertilization at the molecular level.

The structures of secretory and dimeric IgA reveal pseudosymmetric assemblies of two antibody monomers, in which possible positions of antigen-binding fragments and accessibility to receptor-binding sites are limited.

Cryo-EM reveals the regulation of RUVBL1 and RUVBL2 AAA-ATPases by DHX34, a helicase involved in nonsense-mediated mRNA decay (NMD), and suggests mechanisms for how RUVBL1 and RUVBL2 function in NMD.

Fertilizing mouse spermatozoa, characterized by intact CatSper channels, lack of protein tyrosine phosphorylation, and reacted acrosomes, in the female reproductive tract provide molecular insight into sperm selection for successful fertilization.

Crosslinking the AAA+ protease interface does not abolish protein degradation by ClpAP, establishing that rotation of the AAA+ unfoldase with respect to its partner peptidase is not essential for activity.

A comprehensive structural analysis of inhibitory murine antibody 3D11 binding to Plasmodium berghei circumsporozoite protein reveals common mechanisms of antibody evolution in mammals against Plasmodium parasites.