Functional and mechanistic analyses reveal that intranasal decoys engage phagocytic clearance beyond viral neutralization to provide effective protection, establishing immune redirection for developing broad-spectrum countermeasures against airborne viral threats.
An evolution-guided framework is proposed to accelerate the discovery and therapeutic targeting of understudied dark channels by integrating sequence, structure, and functional data from diverse organisms.
Addictive drugs, as well as ketamine/xylazine, change the connectivity to ventral tegmental area dopamine cells, which may be related to cellular activity.
Biochemical and genetic evidence identifies ATP5I as a biguanide target, redefining biguanide action through ATP synthase regulation and assembly, mitochondrial architecture, and mitochondrial protein turnover.
