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    1. Neuroscience

    Adaptive behavior is guided by integrated representations of controlled and non-controlled information

    Bingfang Huang, Harrison Ritz, Jiefeng Jiang
    Revised
    Reviewed Preprint v2
    Updated
    • Useful
    • Incomplete
    1. Developmental Biology
    2. Neuroscience

    Cell cycle-dependent cues regulate temporal patterning of the Drosophila central brain neural stem cells

    Gonzalo N Morales Chaya, Mubarak Hussain Syed
    Intrinsic cell cycle progression governs developmental time in neural stem cells by regulating temporal gene transitions that generate neural diversity.
    1. Neuroscience

    Unravelling the neurocognitive mechanisms underlying counterconditioning in humans

    Lisa Wirz, Maxime C Houtekamer ... Erno Hermans
    Counterconditioning improved safety memory retrieval over regular extinction, showing a shift away from vmPFC towards nucleus accumbens, and may thereby be a promising new treatment option.
    1. Cell Biology
    2. Immunology and Inflammation

    Male-biased Cyp17a2 orchestrates antiviral sexual dimorphism in fish via STING stabilization and viral protein degradation

    Long-Feng Lu, Bao-jie Cui ... Shun Li
    Cyp17a2 enhances antiviral responses in male zebrafish by stabilizing STING through TRIM11-mediated K33-linked polyubiquitination, boosting IFN production.
    1. Neuroscience

    The basolateral amygdala complex and perirhinal cortex represent focal and peripheral states of information processing in rats

    Francesca S Wong, Simon Killcross ... Nathan M Holmes
    The basolateral amygdala complex and perirhinal cortex function like the focal and peripheral states of attention described by classic associative learning theories.
    1. Computational and Systems Biology

    Ribosome demand links transcriptional bursts to protein expression noise

    Sampriti Pal, Upasana Ray, Riddhiman Dhar
    Propagation of expression noise from mRNA to protein level is influenced by variation in availability of ribosomal machinery.
    1. Genetics and Genomics
    2. Neuroscience

    Impaired excitability of fast-spiking neurons in a novel mouse model of KCNC1 epileptic encephalopathy

    Eric R Wengert, Sophie R Liebergall ... Ethan M Goldberg
    Brain slice electrophysiology, immunohistochemistry, and in vivo two-photon calcium imaging identify circuit dysfunction and epilepsy mechanism in a Kcnc1-A421V/+ mouse model of developmental and epileptic encephalopathy.
    1. Neuroscience

    Dynamics of sensorimotor plasticity during spatial finger augmentation

    Dominika Radziun, Siebe Geurts ... Luke E Miller
    Not revised
    Reviewed Preprint v1
    • Useful
    • Solid
    1. Cell Biology
    2. Physics of Living Systems

    Convergent Cellular Adaptation to Freeze-Thaw Stress via a Quiescence-like State in Yeast

    Charuhansini Tvishamayi, Farhan Ali ... Shashi Thutupalli
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Convincing
    1. Biochemistry and Chemical Biology

    Distinct Mechanisms for Inhibition of SARS-CoV-2 Main Protease: Dimerization Promoted by Peptidomimetic Inhibitors and Disrupted by Ebselen

    Chengxi Liu, Qinyu Jia ... Zhong-Ping Yao
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    • Incomplete