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    1. Neuroscience

    Inhibitory circuits control leg movements during Drosophila grooming

    Durafshan Sakeena Syed, Primoz Ravbar, Julie H Simpson
    Anatomical and behavioral characterization of inhibitory neurons in the Drosophila ventral nerve cord shows their critical, diverse roles in limb coordination.
    1. Chromosomes and Gene Expression

    Structural characterisation of chromatin remodelling intermediates supports linker DNA-dependent product inhibition as a mechanism for nucleosome spacing

    Amanda L Hughes, Ramasubramanian Sundaramoorthy, Tom Owen-Hughes
    Structures of the chromatin remodelling enzyme Chd1 during ongoing reactions reveal a reaction pathway tuned to generate nucleosome spacing similar to that observed in cells.
    1. Neuroscience

    Multimodal MRI Marker of Cognition Explains the Association Between Cognition and Mental Health in UK Biobank

    Irina Buianova, Mateus Silvestrin ... Narun Pat
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Compelling
    1. Neuroscience

    Energy Landscape Analysis Reveals Thalamic Modulation of Brain State Transitions During Movie Watching

    Qiuyi Liu, Lili Sun ... Xia Liang
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Microbiology and Infectious Disease

    A rapid transfer of virions coated with heparan sulfate from the ECM to CD151 defines an early step in the human papillomavirus infection cascade

    Annika Massenberg, Yahya Homsi ... Thorsten Lang
    Revised
    Reviewed Preprint v2
    Updated
    • Valuable
    • Solid
    1. Cancer Biology

    Identifying tissue states by spatial protein patterns related to chemotherapy response in triple-negative breast cancer

    Luciana M Luque, Mohammad Asif Khan ... Linus J Schumacher
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Cell Biology

    Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

    Kanako Shinno, Yuri Miura ... Kanae Ando
    Upregulation of the β subunit of translation initiation factor eIF2 underlies autophagy suppression and premature aging caused by disruption of axonal transport of mitochondria.
    1. Biochemistry and Chemical Biology

    Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity

    Gabriel M Kline, Lisa Boinon ... R Luke Wiseman
    Establishment of AA263 analogs with improved potential for correcting pathologic disruptions of endoplasmic reticulum proteostasis implicated in the onset and pathogenesis of etiologically diverse diseases.
    1. Neuroscience

    Sex-specific exploration accounts for differences in valence learning in male and female mice

    Heike Schuler, Eshaan S Iyer ... Rosemary C Bagot
    Deep behavioral phenotyping reveals that performance readouts from single-valence conditioning are biased by baseline sex differences in exploration, and mixed-valence conditioning provides a clearer assessment of learning in both sexes.
    1. Microbiology and Infectious Disease

    Activation of the Spx redox sensor counters cysteine-driven Fe(II) depletion under disulfide stress

    Abigail G Hall, Abdulelah A Alqarzaee ... Vinai C Thomas
    Not revised
    Reviewed Preprint v1
    • Important
    • Compelling
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