Warming and altered precipitation reduce the growth rates of alpine soil bacteria by 40-90%, and the growth of ~70% taxa is influenced by antagonistic interactions between factors.
Evolution-guided structure-function analyses reveal that CD4 transmembrane and intracellular juxtamembrane motifs play a more profound role in initiating pMHCII-specific TCR-CD3 signaling than previously characterized CD4-Lck interactions.
Using sequence-determined functional genomic features instead of original genotypes can partially overcome challenges in genetic association studies, such as rare variant exclusion and population structure.
Detailed molecular characterization of a constitutively active bacterial NADPH oxidase (NOX) provides clues to the activation mechanism required to trigger electron transfer and reactive oxygen species (ROS) production in tightly regulated eukaryotic NOX.
A forebrain nucleus contributes specifically to the variability of syllable sequencing in songs of Bengalese finches, a songbird with complex syntactic song structure.
Edgar M Pera, Josefine Nilsson-De Moura ... Ivana Milas
An extracellular proteolytic pathway involving the serine protease HtrA1, its inhibitor SerpinE2, and the transmembrane proteoglycan Syndecan-4 control collective migration of neural crest cells in the developing embryo.
