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    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins

    Mathew Thayer, Michael B Heskett ... Phillip A Yates
    Molecular genetic analyses of ASARs reveals regulation of large-scale mammalian chromosome structure and function that includes long non-coding RNAs and nuclear RNA binding proteins as essential regulators of chromosome dynamics.
    1. Physics of Living Systems

    Diffusive lensing as a mechanism of intracellular transport and compartmentalization

    Achuthan Raja Venkatesh, Kathy H Le ... Onn Brandman
    Agent-based modeling of space-dependent diffusivity inside cells reveals potential effects on biomolecule concentration and mesoscale dynamics.
    1. Immunology and Inflammation

    Fine-tuning spatial-temporal dynamics and surface receptor expression support plasma cell-intrinsic longevity

    Zhixin Jing, Phillip Galbo ... David Fooksman
    Enigmatic long-lived plasma cells display an enhanced clustering in bone marrow niches and require CXCR4 for retention, survival, and maintenance of antibody titers.
    1. Cancer Biology
    2. Cell Biology

    SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells

    Linda Zhang, Joanne I Hsu ... Margaret A Goodell
    PPM1D-mutant leukemia cells exhibit a dysregulated redox landscape, a diminished response to oxidative stress, and rely on SOD1 for their survival.
    1. Plant Biology

    A dual function of the IDA peptide in regulating cell separation and modulating plant immunity at the molecular level

    Vilde Olsson Lalun, Maike Breiden ... Melinka A Butenko
    A molecular investigation on the role of the peptide ligand inflorescence deficient in abscission (IDA) in regulating immunity and development during cell separation in Arabidopsis thaliana.
    1. Cell Biology
    2. Developmental Biology

    The Drosophila EcR-Hippo component Taiman promotes epithelial cell fitness by control of the Dally-like glypican and Wg gradient

    Colby K. Schweibenz, Victoria C. Placentra, Kenneth H. Moberg
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Immunology and Inflammation

    Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity

    Leen Farhat-Younis, Manho Na ... Yaron Carmi
    Genetic engineering of murine myeloid cells reveals the challenges in ectopic expression of chemiric receptors and provides a novel framework to endow them with tumor-specific cytotoxic ability.
    1. Neuroscience

    Homeostatic regulation of rapid eye movement sleep by the preoptic area of the hypothalamus

    John J Maurer, Alexandra Lin ... Shinjae Chung
    Preoptic area of the hypothalamus is important for the homeostatic regulation of rapid eye movement sleep.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural characterization of ligand binding and pH-specific enzymatic activity of mouse Acidic Mammalian Chitinase

    Roberto Efraín Díaz, Andrew K Ecker ... James S Fraser
    Biochemical and structural investigations of the pH adaptability of mouse Acidic Mammalian Chitinase offer insights for designing enhanced enzyme variants that can function in both lung and gut.
    1. Cell Biology
    2. Genetics and Genomics

    Temporally controlled nervous system-to-gut signaling bidirectionally regulates longevity in C. elegans

    Lingxiu Xu, Chengxuan Han ... Jianfeng Liu
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete