The peptidoglycan hydrolase activity of Enterococcus faecium secreted antigen A is crucial for cell wall remodeling during bacterial cell separation and generates muropeptides that stimulate host immunity to enhance immune checkpoint inhibitor anti-cancer therapy.
A novel bilinear modeling approach reveals genetic code of neuronal connectivity, offering insights for targeted genetic interventions in neural circuits.
Single-cell RNA sequencing analysis of diabetic mouse cavernous tissue revealed that LBH is a novel pericyte marker and may interact with Crystallin Alpha B and Vimentin to promote neurovascular regeneration.
Weiting Zhang, Karl Petri ... Jing-Ruey Joanna Yeh
Strategic pegRNA designs and other approaches mitigating 5' and 3' interactions within pegRNAs can often lead to substantial improvements in prime editing efficiency.
Yi-Ting Chang, Eric A Finkel ... Daniel H O'Connor
Preparatory states within the motor cortex play a critical role in selecting an appropriate action in response to sensory input, dependent on the context.