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High-resolution NMR data and precise kinase activity assays on Abelson kinase bearing mutations in its αI-helix identify the αI-helix parts involved in disassembly of Abelson’s regulatory core and kinase activation.

Single nuclei RNA sequencing unmasks 16 variants of midbrain dopamine neurons within a continuum of their gene expression landscape and resolves their differential vulnerability.

The BTB zinc finger gene Bm-mamo regulates melanin pigmentation in silkworm caterpillars from multiple aspects, including melanin synthesis, pigment granules maturation, and cuticle construction.

A novel hydrogel-based platform uses a limited number of cells for tissue generation and offers unique advantages for high-throughput cardiac tissue culture.

DePARylation is essential for cell survival and thus poly(ADP-ribose) glycohydrolase (PARG) expression correlates with cytotoxicity induced by PARG inhibition, which will benefit the development of PARG inhibitors for cancer treatment.

Primary endothelial cell cultures contain markedly heterogeneous cell subtypes that exhibit distinct molecular responses to disease-relevant exposures.

Structural insights into the orthosteric inhibition and subtype specificity of P2X receptors by classical P2X antagonists facilitate the rational design of novel competitive antagonists for P2X receptors.

Individuals with higher blood levels of omega-3 and omega-6 fatty acids, especially omega-3, are less likely to die, either from any cause, cancer or cardiovascular disease.

Structural representations of sentences generated by deep language models correlate with human listeners' behaviours and neural activity, providing a quantifiable framework to uncover the neural dynamics underpinning incremental speech comprehension.

Cell type-specific effects of antipsychotic drugs in cortex could provide a basis for a functional screen of antipsychotic efficacy.