Matthew F Wipperman, Allen Z Lin ... Olivier Harari
Biosensor data collected by digital insoles is comparable to lab-based clinical assessments and can be used to identify subject-specific gait patterns.
Ivan Castello-Serrano, Frederick A Heberle ... Ilya Levental
Direct measurements of trafficking kinetics between organelles of the secretory pathway suggest that lipid-driven membrane domains laterally sort proteins during membrane traffic.
Conditional abolishment of a G protein subunit in a subset of ectopic tuft cells engenders severer injury, slower recovery, and increased fatality following the infection of the influenza viruses.
A combined theoretical and experimental study revealed the mechanistic and structural basis of mutational effects on allostery and provided insights into the intrinsic connection of intra- and inter-domain properties.
Pascal Forcella, Niklas Ifflander ... Verdon Taylor
Extensive analysis shows that the RNA-binding protein SAFB binds to Drosha in hippocampal stem cells and controls oligodendrocyte fate commitment through post-transcriptional regulation of NFIB expression.
Individual olfactory-driven behaviors, odor preferences, and olfactory sensitivity have rapidly evolved in blind Mexican cavefish, as a quantitative genetic trait.
Rafael F Guerrero, Tandin Dorji ... C Brandon Ogbunugafor
Inspired by notions of 'druggability' from medicinal chemistry, two new metrics, drug applicability and variant vulnerability, utilize evolutionary perspectives and methods to improve attempts to treat infectious diseases.
