Browse our latest research

Page 383 of 1,810
    1. Neuroscience

    Optogenetic stimulation of the locus coeruleus enhances appetitive extinction in rats

    Simon Lui, Ashleigh K Brink, Laura H Corbit
    The long-term retention of extinction is enhanced by ontogenetic stimulation of locus coeruleus neurons applied during extinction of a reward-seeking response, further implicating noradrenaline in appetitive extinction.
    1. Neuroscience

    Towards biologically plausible phosphene simulation for the differentiable optimization of visual cortical prostheses

    Maureen van der Grinten, Jaap de Ruyter van Steveninck ... Yağmur Güçlütürk
    The provided framework based on biological models and clinical literature can aid in the optimization of visual cortical prostheses through computational or behavioral simulation experiments, serving as a flexible tool for computational, clinical, and behavioral neuroscientists working on visual neuroprosthetics.
    1. Cell Biology

    Rapid binding to protofilament edge sites facilitates tip tracking of EB1 at growing microtubule plus-ends

    Samuel J Gonzalez, Julia M Heckel ... Melissa K Gardner
    Computational modeling combined with biophysical and cellular experiments reveal that rapid binding to incomplete, partial microtubule binding sites facilitates tracking of the end-binding protein EB1 with growing microtubule plus-ends.
    1. Immunology and Inflammation

    Tailoring Tfh profiles enhances antibody persistence to a clade C HIV-1 vaccine in rhesus macaques

    Anil Verma, Chase E Hawes ... Smita S Iyer
    Strategies to enhance Tfh cells for HIV-vaccine antibody persistence and protection is pivotal for vaccine success.
    1. Developmental Biology
    2. Neuroscience

    Touch receptor end-organ innervation and function require sensory neuron expression of the transcription factor Meis2

    Simon Desiderio, Frederick Schwaller ... Frederic Marmigere
    Combining mouse genetic, behavioral, and electrophysiological approaches revealed that a transcription factor is required to shape touch neurons' distal projections in the skin while dispensable for their survival and specification.
    1. Cell Biology
    2. Plant Biology

    Developmental patterning function of GNOM ARF-GEF mediated from the cell periphery

    Maciek Adamowski, Ivana Matijević, Jiří Friml
    The plant developmental regulator GNOM performs its unique function from the cell periphery, through sequence features present in all its domains, and not by the control of endocytosis.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Energetics of the microsporidian polar tube invasion machinery

    Ray Chang, Ari Davydov ... Manu Prakash
    Unraveling the ultrafast polar tube ejection in microsporidia reveals extreme cellular hydraulics, providing a data-driven model for infectious cargo transport, with implications for physical approaches to understanding microsporidia transmission.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Autotrophic growth of Escherichia coli is achieved by a small number of genetic changes

    Roee Ben Nissan, Eliya Milshtein ... Ron Milo
    Achieving autotrophy in E. coli by introducing a small number of genetic changes crosses a milestone in engineering major metabolic transitions and paves a way for sustainable bio-production from CO2.
    1. Structural Biology and Molecular Biophysics

    Mobile barrier mechanisms for Na+-coupled symport in an MFS sugar transporter

    Parameswaran Hariharan, Yuqi Shi ... Lan Guan
    The use of a conformation-selective inhibitory nanobody provides critical information on MelB at a low-sugar affinity inward-facing Na+-bound state for establishing the mobile barrier and substrate-releasing mechanisms.
    1. Neuroscience

    Sexual coordination in a whole-brain map of prairie vole pair bonding

    Morgan L Gustison, Rodrigo Muñoz-Castañeda ... Steven M Phelps
    A brain-wide map of neural activation reveals how sexual experience becomes a pair bond in the monogamous prairie vole.