Browse our latest research

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    1. Neuroscience

    A system of feed-forward cerebellar circuits that extend and diversify sensory signaling

    Harsh N Hariani, A Brynn Algstam ... Timothy S Balmer
    Unipolar brush cells subtypes, classified by their excitatory or inhibitory response to glutamate, form circuits with one another that may enhance the capacity of the cerebellum to transform input signals.
    1. Neuroscience

    New genetic tools for mushroom body output neurons in Drosophila

    Gerald M Rubin, Yoshinori Aso
    Improved cell-type-specific genetic drivers for the study of learning and memory and other complex behaviors in Drosophila are provided and validated.
    1. Neuroscience

    Involvement of superior colliculus in complex figure detection of mice

    J Leonie Cazemier, Robin Haak ... J Alexander Heimel
    Mouse superior colliculus is involved in figure detection based on differences in contrast and texture orientation and phase.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Comparative interactome analysis of α-arrestin families in human and Drosophila

    Kyung-Tae Lee, Inez KA Pranoto ... Jin-Wu Nam
    Unveiling the high-confidence protein–protein interaction networks of human and fly α-arrestins provides insights into conserved and species-specific functional roles depending on their protein domains and motifs.
    1. Microbiology and Infectious Disease

    A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

    Clare Andradi-Brown, Jan Stephan Wichers-Misterek ... Anna Bachmann
    An enhanced bioinformatic pipeline to quantify Plasmodium falciparum core gene and polymorphic var gene expression revealed changes occurring during early culture adaptation of parasites from naturally infected individuals.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Light-inducible protein degradation in E. coli with the LOVdeg tag

    Nathan Tague, Cristian Coriano-Ortiz ... Mary J Dunlop
    The LOVdeg tag is a versatile tool for bacterial optogenetics, offering modular, blue light-inducible protein degradation for a range of synthetic biology and metabolic engineering applications.
    1. Cell Biology
    2. Developmental Biology

    Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice

    Longjie Sun, Zheng Lv ... Jiali Liu
    SRSF1 plays a critical role in posttranscriptional regulation to implement homing of precursor spermatogonial stem cells.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    Maresin 1 repletion improves muscle regeneration after volumetric muscle loss

    Jesus A Castor-Macias, Jacqueline A Larouche ... Carlos A Aguilar
    The treatment of injury from volumetric muscle loss with Maresin 1 reduces inflammation and fibrosis, driving improvements in the recovery of muscle strength.
    1. Neuroscience

    Cell type-specific connectome predicts distributed working memory activity in the mouse brain

    Xingyu Ding, Sean Froudist-Walsh ... Xiao-Jing Wang
    Large-scale modeling of the mouse brain revealed that working memory is modular and determined by long-range cell type-specific connections, thereby providing a framework to interpret brain-wide recordings during cognition.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    A computational method for predicting the most likely evolutionary trajectories in the stepwise accumulation of resistance mutations

    Ruth Charlotte Eccleston, Emilia Manko ... Nicholas Furnham
    A computational method for predicting evolutionary pathways to antimicrobial resistance, accounting for how epistatic interactions determine trajectories, is described.