Uri Seroussi, Andrew Lugowski ... Julie M Claycomb
Systematically studying the expression, small RNA-binding partners, and loss-of-function phenotypes of all 19 Argonautes uncovers how small RNA regulatory pathways function and interact in Caenorhabditis elegans, a long-standing model for small RNA biology and RNAi.
Members of the OTOP family of proton-selective ion channels, which includes the sour receptor OTOP1, are differentially sensitive to activation by zinc, which interacts with residues on tm 5-6 and 11-12 linkers that form part of the channel gating apparatus.
Carol A Edwards, William MD Watkinson ... Anne C Ferguson-Smith
Genes with parent-of-origin specific expression are not as numerous as previously reported and validated parentally-biased expressed genes tend to be peripheral to known imprinted domains indicating shared regional control.
Single-cell transcriptomic profiling of human bone marrow non-hematopoietic cells provides the basis for a comprehensive understanding of the cellular complexity of the hematopoietic stem cell (HSC) microenvironment and the intricate stroma-hematopoiesis crosstalk mechanisms.
Jiawen Huang, Isabel Velarde ... Christopher Baldassano
The development of knowledge for a board game facilitates memory for sequences in the game, demonstrating a new mechanism for the facilitation by enabling complicated predictions.
The structure of the photosystem I (PSI) supercomplex in Ostreococcus tauri has revealed a unique hybrid of both plant-type and green algal-type PSI supercomplexes with three Lhcp trimers located at the ‘state 2’ position.
Mohammad Saeed Zarzor, Ingmar Blumcke, Silvia Budday
Continuum mechanics-based computational modeling provides insights into the interplay between cell proliferation in different zones of the developing human brain and the evolving cortical folding patterns.
A GABAergic neural circuit from AgRP to the dorsomedial hypothalamic nucleus regulates leptin-mediated feeding and energy balance through α3-GABAA signaling, which could provide a new therapeutic avenue for obesity.
Scaling stimulus size based on the extent of its representation in visual cortex eliminates differences in contrast sensitivity and acuity when measured as a function of eccentricity, but not when measured as a function of polar angle.
Targeted therapies induce an aberrant fucosylation of complex tumor secretomes stimulating the expansion of minority drug-resistant clones and promoting therapy resistance.
