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The study of the interactions between 65,356 variants of the SARS-CoV-2 receptor binding domain and a panel of monoclonal antibodies shows that Omicron’s escape is driven by a small number of large effect mutations.

Chondrocytes derived from induced pluripotent stem cells with the dysplasia-causing TRPV4 mutations, V620I and T89I mutation, were resistant to BMP4-induced hypertrophy, suggesting a mechanism underlying the effects of TRPV4 dysfunction on the severity of skeletal dysplasia.

Expression patterns and biophysical properties of acid-sensing ion channels in numerous bilaterian animals offer insight into the deployment of ion channels by the evolving nervous system in complex animals.

The loss of miRNA-27a stimulates osteoclast-mediated bone resorption but does not affect osteoblast-mediated bone formation, leading to the development of osteoporosis in mice.

Activity-based inhibitors, in conjunction with new experimental and computational tools, enable the discovery of mechanisms involved in DNMT1 autoinhibition.

Some Burkholderia thailandensis strains have evolved a bet-hedging strategy by acquiring insertion sequences positioned such that RecA-dependent homologous recombination between them results in duplication of intervening sequences, which promotes biofilm formation.

Oligodendrocyte-lineage cells secrete L-type prostaglandin synthase in an autocrine loop to promote oligodendrocyte development and myelination.

Microglia that presumably sense neuronal activity via detection of glutamate at synapses in the hippocampus show higher fine process motility and increased contact rates associated with formation and elimination of dendritic spines under conditions of elevated neuronal activity.

Divisive normalisation effects on decision making caused by distractor options can be reduced by stimulating the parietal cortex using transcranial magnetic stimulation.

The overall mortality consequences of the COVID-19 pandemic in the United States are predominantly attributable to the direct impact of SARS-CoV-2 infection but there are substantial indirect effects among children and young adults, and in mortality from accidents, homicides, and overdoses.