Browse our latest research

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    1. Neuroscience

    Microglial motility is modulated by neuronal activity and correlates with dendritic spine plasticity in the hippocampus of awake mice

    Felix Christopher Nebeling, Stefanie Poll ... Martin Fuhrmann
    Microglia that presumably sense neuronal activity via detection of glutamate at synapses in the hippocampus show higher fine process motility and increased contact rates associated with formation and elimination of dendritic spines under conditions of elevated neuronal activity.
    1. Neuroscience
    2. Developmental Biology

    Intraparietal stimulation disrupts negative distractor effects in human multi-alternative decision-making

    Carmen Kohl, Michelle XM Wong ... Bolton KH Chau
    Divisive normalisation effects on decision making caused by distractor options can be reduced by stimulating the parietal cortex using transcranial magnetic stimulation.
    1. Epidemiology and Global Health

    Direct and indirect mortality impacts of the COVID-19 pandemic in the United States, March 1, 2020 to January 1, 2022

    Wha-Eum Lee, Sang Woo Park ... Cécile Viboud
    The overall mortality consequences of the COVID-19 pandemic in the United States are predominantly attributable to the direct impact of SARS-CoV-2 infection but there are substantial indirect effects among children and young adults, and in mortality from accidents, homicides, and overdoses.
    1. Cancer Biology
    2. Immunology and Inflammation

    Proliferative exhausted CD8+ T cells exacerbate long-lasting anti-tumor effects in human papillomavirus-positive head and neck squamous cell carcinoma

    Danni Cheng, Ke Qiu ... Jianjun Ren
    Multi-omic profiling of tumor-infiltrating T cells provides new insights into the differences in the effectiveness of CDK4 inhibitor between human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma patients.
    1. Neuroscience

    Targeted anatomical and functional identification of antinociceptive and pronociceptive serotonergic neurons that project to the spinal dorsal horn

    Robert Philip Ganley, Marilia Magalhaes de Sousa ... Hanns Ulrich Zeilhofer
    Two populations of serotonergic neurons are present in the medial and lateral hindbrain, which are shown to project to distinct spinal cord regions and have opposing effects on nociception in mice.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Balancing selection on genomic deletion polymorphisms in humans

    Alber Aqil, Leo Speidel ... Omer Gokcumen
    The effect of balancing selection on the human genome is greater than previously appreciated, especially affecting large deletion variations.
    1. Cell Biology

    The termination of UHRF1-dependent PAF15 ubiquitin signaling is regulated by USP7 and ATAD5

    Ryota Miyashita, Atsuya Nishiyama ... Makoto Nakanishi
    The cooperative action of PAF15 deubiquitylation by USP7 and its dissociation from chromatin by ATAD5 regulates proper PAF15Ub2 signaling termination, which is important for replication and maintenance of DNA methylation.
    1. Developmental Biology

    Renal interstitial cells promote nephron regeneration by secreting prostaglandin E2

    Xiaoliang Liu, Ting Yu ... Chi Liu
    During nephron regeneration, renal interstitial cells promote the proliferation of renal progenitor cells by secreting PGE2, thus forming the microenvironment of renal progenitor cells.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Directed differentiation of human iPSCs to functional ovarian granulosa-like cells via transcription factor overexpression

    Merrick D Pierson Smela, Christian C Kramme ... George M Church
    Making human stem cells express certain transcription factors can convert them into cells that are similar to ovarian granulosa cells, and perform several important functions of the ovary.
    1. Physics of Living Systems

    Nuclear export inhibition jumbles epithelial–mesenchymal states and gives rise to migratory disorder in healthy epithelia

    Carly M Krull, Haiyi Li, Amit Pathak
    Nuclear export inhibition reveals concurrent epithelial and mesenchymal phenotypes that cause mechanosensitive disorder in collectively migrating epithelia.