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    1. Physics of Living Systems

    Nuclear export inhibition jumbles epithelial–mesenchymal states and gives rise to migratory disorder in healthy epithelia

    Carly M Krull, Haiyi Li, Amit Pathak
    Nuclear export inhibition reveals concurrent epithelial and mesenchymal phenotypes that cause mechanosensitive disorder in collectively migrating epithelia.
    1. Cancer Biology

    The role of macrophages in non-small cell lung cancer and advancements in 3D co-cultures

    Katarína Balážová, Hans Clevers, Antonella FM Dost
    As macrophages are involved in various aspects of non-small cell lung cancer development and progression it is crucial to develop appropriate 3D co-culture platforms for modeling immune cell-tumor cell interactions, leading to more efficacious macrophage-focused immunotherapies.
    1. Neuroscience

    Cerebrospinal fluid-contacting neuron tracing reveals structural and functional connectivity for locomotion in the mouse spinal cord

    Yuka Nakamura, Miyuki Kurabe ... Masaki Ueno
    Newly developed methods to genetically target cerebrospinal fluid-contacting neurons reveal unique caudorostrally extended projections and recurrent connections in the spinal motor circuitry to control locomotion in mice.
    1. Physics of Living Systems

    Geometric control of myosin II orientation during axis elongation

    Matthew F Lefebvre, Nikolas H Claussen ... Sebastian J Streichan
    During Drosophila axis elongation, the orientational pattern of the cytoskeleton is in good approximation stationary, while the genes thought to instruct these patterns are transported with the tissue flow.
    1. Cell Biology
    2. Physics of Living Systems

    Novel analytical tools reveal that local synchronization of cilia coincides with tissue-scale metachronal waves in zebrafish multiciliated epithelia

    Christa Ringers, Stephan Bialonski ... Nathalie Jurisch-Yaksi
    Novel frequency-based analysis and computation modeling of cilia carpets reveals that tissue-scale metachronal coordination of cilia can arise even in the absence of global synchronization.
    1. Neuroscience

    Neural assemblies uncovered by generative modeling explain whole-brain activity statistics and reflect structural connectivity

    Thijs L van der Plas, Jérôme Tubiana ... Georges Debrégeas
    A data-driven network model offers an interpretable and physiologically sound description of the whole-brain spontaneous neural activity of zebrafish larvae.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    CriSNPr, a single interface for the curated and de novo design of gRNAs for CRISPR diagnostics using diverse Cas systems

    Asgar H Ansari, Manoj Kumar ... Debojyoti Chakraborty
    The web-server CriSNPr overcomes difficulties associated with the different CRISPR diagnostic platforms that stem from Cas-specific single guide RNA design parameters, thereby minimizing the time and effort required for individual assay design.
    1. Epidemiology and Global Health
    2. Medicine

    Antibody levels following vaccination against SARS-CoV-2: associations with post-vaccination infection and risk factors in two UK longitudinal studies

    Nathan J Cheetham, Milla Kibble ... Claire J Steves
    Third SARS-CoV-2 vaccination appears to eliminate disparities in anti-Spike antibodies between those who received Pfizer-BioNTech versus Oxford/AstraZeneca for first and second vaccination, but levels remain lower in certain groups such as those on the UK 'Shielded Patient List'.
    1. Neuroscience

    Pallidal neuromodulation of the explore/exploit trade-off in decision-making

    Ana Luisa de A Marcelino, Owen Gray ... Tom Gilbertson
    Deep brain stimulation (DBS) exhibit that the excitability of the basal ganglia can govern the trade off between exploiting available resources or exploring alternative courses of action.
    1. Cell Biology
    2. Neuroscience

    Pericytes control vascular stability and auditory spiral ganglion neuron survival

    Yunpei Zhang, Lingling Neng ... Xiaorui Shi
    Pericytes in the adult ear are critical for vascular stability and spiral ganglion neuron health.