Xiao Lei, Daniel Gonçalves-Carneiro ... Paul D Bieniasz
Initiation of the assembly of HIV-1 particles in infected cells is required to form a subviral structure that recognizes the viral RNA genome for packaging.
Individual and situational differences in altruistic behavior do not reflect use of fundamentally different decision mechanisms, but instead differences in early perceptual or attentional processing of the choice-relevant information.
The expression of DECTIN-2 family C-type lectin receptors on macrophages and monocytes is inhibited by the Th2 cytokine IL-4, which suggests a mechanism for inhibition of Th17 responses to MINCLE-dependent vaccination responses by underlying helminth infection.
A user-friendly, and modular, 3D skeletal muscle culture assay enables iterative studies of murine muscle stem cell pool size regulation, functional heterogeneity, return to quiescence, and age-associated functional defects within a 96-well footprint.
Marina Ainciburu, Teresa Ezponda ... Felipe Prosper
Single-cell transcriptomics reveals altered pathways, gene expression dynamics, and activation of transcriptional programs in human early hematopoiesis during healthy aging and myelodysplastic syndromes.
Jingyi Guo Fuglstad, Pearl Saldanha ... Jonathan R Whitlock
HERBS is a catch-all anatomical registration toolkit allowing users to plan surgical coordinates in advance, or visualize anatomical data post hoc in 2D or 3D brain volumes for rats, mice, or any species that has a compatible atlas.
The participation in cervical cancer screening in Denmark was reduced at the start of the pandemic although with longer follow-up time most women resumed screening.
Nathaniel J Himmel, Akira Sakurai ... Daniel N Cox
Anoctamin/TMEM16 and SLC12 co-transporter genes selectively function in regulating cold nociception via excitatory chloride currents and can promote neuropathic sensitization phenotypes, including behavioral sensitization and neuronal hyperexcitability in Drosophila multimodal sensory neurons.
Reactivation of paternal Ube3a by an ASO therapy in juvenile and adult mouse models of Angelman syndrome reverses the impairments of EEG power spectrum and sleep pattern, suggesting that these two core disease features may be improved by such therapies.
