Browse our latest research

Early-life exposure to conspecific urine and bedding extends the lifespan of female mice, indicating that social chemosensory cues can influence aging in a mammal.

Biochemical studies and molecular dynamics simulations indicate that dephosphroylation of F-BAR protein Cdc15 promotes cytokinesis ring assembly in yeast via conformation change of intrinsically disorder regions and condensate formation.

The rational drug design combining the bioassay identified a novel selective androgen receptor (AR) degrader for both AR and AR-VRs and illustrated the synergistic importance of AR antagonism and degradation in advanced prostate cancer treatment.

A hallmark property of non-functional clonotypes was used to develop a universal and fully computational method for detection and correction of multiplex PCR-specific quantitative bias in adaptive immune receptor repertoire.

A high-throughput analysis of several self-cleaving ribozymes reveals the effect of every possible mutation, and every possible pair of mutations, and how patterns in the relative activity data can be mapped to canonical and non-canonical structural elements.

Molecular, cellular, and developmental characterization of zebrafish Merkel cells establishes a new model for the study of mechanosensory epidermal cells.

Behavioral and neurophysiological recordings in infant rats reveal that sleep and sensory experience influence neural activity in prefrontal cortex, mirroring similar findings in developing sensorimotor cortex.

Tools and resources to identify transcriptional regulators that create and maintain differences between photoreceptor subtypes.

Endocrine therapy after mastectomy may not be recommended for patients with hormone receptor positive ductal carcinoma in situ, even for those with high-risk factors.

ELYS, a multifunctional protein with critical roles in the cell cycle, is essential for the vigorous proliferation and survival of difficult-to-treat cancers carrying mutations in the KRAS oncogene, making it a compelling target for novel drug treatments.