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The structure of the yeast HOPS tethering complex suggests how this large complex may catalyze fusion by tethering Rab-decorated membranes and promoting the assembly of SNAREs.

A genetic manipulation of the Nrxn1/3^SS4+-Cbln1/2 complex reveals this signaling pathway has no role in synapse formation but functions to shape the NMDAR- and AMPAR-content at multiple types of synapses with distinct facets in diverse circuits.

Microfluidics and dynamic imaging allow systematic characterization of polarization kinetics in B lymphocytes and highlight the role of microtubules as master regulators of actin polymerization at the immune synapse.

An ellipse of insignificant analysis is a robust method for ascertaining the strength of even large dichotomous outcome trials in biomedical science, and is a novel means to detect potentially dubious results and research fraud.

Pre-existing variability in the regulation of non-rapid eye movement sleep predicts resilience to social-defeat stress.

Cohesin role in chromosome organisation during anaphase is necessary for the segregation of chromosomes.

A subset of intestinal precursor cells is able to sense mechanical forces at cell–cell junctions to control the production of specialised cells.

The DCC-SMLM algorithm allows to determine protein oligomeric states in situ, using the information obtained from the colocalization of fluorescent markers, overcoming the need for extraction of proteins from cells or complicated experimental setups when using microscopy.

A highly efficient platform to engineer designer mutations in human stem cells using RNA-based delivery of prime editing components.

The chromatin regulator WDR5 is a regulator of translation, and small molecule inhibitors or degraders of WDR5 can be used to treat triple-negative breast cancer.