Browse our latest research

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    1. Microbiology and Infectious Disease

    Genetic and chemical validation of Plasmodium falciparum aminopeptidase PfA-M17 as a drug target in the hemoglobin digestion pathway

    Rebecca CS Edgar, Ghizal Siddiqui ... Tania F de Koning-Ward
    Plasmodium falciparum aminopeptidase PfA-M17 is essential to parasite survival and plays a role in hemoglobin digestion, providing a rationale for further development of inhibitors against this enzyme.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Regional importation and asymmetric within-country spread of SARS-CoV-2 variants of concern in the Netherlands

    Alvin X Han, Eva Kozanli ... Chantal Reusken
    Flight restrictions targeted at countries where SARS-CoV-2 variant-of-concern first emerged have limited effectiveness in deterring their introduction into the Netherlands due to the strength of regional travel importation risks in Europe.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Eco-evolutionary dynamics of clonal multicellular life cycles

    Vanessa Ress, Arne Traulsen, Yuriy Pichugin
    The evolution of clonal multicellular life cycles, whose growth is constrained by competition, may lead to coexistence or multistability between several life cycles while evolutionarily stable strategies can be inferred from the analysis of a model with unconstrained growth.
    1. Developmental Biology

    Innexin function dictates the spatial relationship between distal somatic cells in the Caenorhabditis elegans gonad without impacting the germline stem cell pool

    Theadora Tolkin, Ariz Mohammad ... David Greenstein
    Somatic gonad architecture is regulated by innexin function, but sheath cell position does not determine germ cell exit from the stem cell pool.
    1. Neuroscience

    The role of anterior insular cortex inputs to dorsolateral striatum in binge alcohol drinking

    David L Haggerty, Braulio Munoz ... Brady K Atwood
    A novel brain circuit that determines how much alcohol a mouse binge drinks by complex control of drinking behavior mechanics is surveyed.
    1. Structural Biology and Molecular Biophysics

    Mars, a molecule archive suite for reproducible analysis and reporting of single-molecule properties from bioimages

    Nadia M Huisjes, Thomas M Retzer ... Karl E Duderstadt
    Mars provides a software platform for the development of complex single-molecule analysis workflows enabling the discovery and reporting of new biological phenomena with an open data format accessible to everyone.
    1. Cell Biology
    2. Computational and Systems Biology

    A unified view of low complexity regions (LCRs) across species

    Byron Lee, Nima Jaberi-Lashkari, Eliezer Calo
    Disparate functions of low complexity regions of proteins can be understood through a global view of their sequences, features, and relationships across different organisms and biological contexts.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Estimation and worldwide monitoring of the effective reproductive number of SARS-CoV-2

    Jana S Huisman, Jérémie Scire ... Tanja Stadler
    A new and throughly validated method for timely estimation of the effective reproductive number of SARS-CoV-2 aided in the public health response to the COVID-19 pandemic.
    1. Evolutionary Biology
    2. Physics of Living Systems

    Design of an optimal combination therapy with broadly neutralizing antibodies to suppress HIV-1

    Colin LaMont, Jakub Otwinowski ... Armita Nourmohammad
    Computational evolutionary model to predict the efficacy of broadly neutralizing antibodies (bNAbs) in suppressing HIV and to design optimal combination therapy with bNAbs.
    1. Neuroscience

    Neural synchronization is strongest to the spectral flux of slow music and depends on familiarity and beat salience

    Kristin Weineck, Olivia Xin Wen, Molly J Henry
    Two different analysis approaches for measuring neural synchronization to natural music revealed strongest synchronization to musical spectral flux as opposed to the more commonly used amplitude envelope.