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An improved culture method for explanted adult Drosophila organs allows the live-imaging of damage response, cell differentiation, and tracing of progenitor cell lineages through multiple rounds of division.

Fat2 signals from the trailing edge of each cell to localize WAVE activity to the leading edge of the cell behind, polarizing protrusive regions within cells and across the epithelium.

Cardiac fibroblast reduction is well-tolerated and demonstrates beneficial outcomes after heart injury.

Parkinson’s disease-associated LRRK2 kinase is recruited to membranes by its Rab GTPase substrates, and LRRK2 is both retained on membranes and further activated there by cooperative interaction with the phosphorylated Rab proteins that it generates.

A poorly understood cell type, the telocyte, is shown to regulate macrophages.

A novel experimental paradigm investigating how humans manage limited search capacity over many alternatives reveals close-to-optimal behaviours and identifies heuristics used to minimize computation with little impact on performance.

Genetically predicted high insulin-like growth factor levels may decrease the risk of COVID-19 susceptibility and hospitalization.

Behavioral, lipidomic, and genetic analyses of adult Drosophila on a chronic high-sugar regime identified that fat body activity of a phospholipid biosynthesis enzyme, Pect, regulates insulin sensitivity and hunger response.

The SPARC complex directs accurate RNAPII positioning for transcription initiation and, in some instances, ensures correct transcription directionality in Trypanosoma brucei.

Transcription factor Zbtb14 plays an important role in monocyte and macrophage development through the modulation of pu.1 expression.