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The ISR kinase GCN2 is critical for maintaining tumor amino acid levels to facilitate growth, suggesting a novel therapeutic strategy for the treatment of prostate cancer by inducing starvation for essential amino acids.

A proteo-genomic CRISPR activation screening workflow to accelerate the identification of novel interactions between the secreted and membrane proteome with the potential to define new biological processes and identify future therapeutic targets.

Across 63 large US cities, street tree communities are shaped by climate, clustered by species, and made more similar between cities due to the presence of introduced species.

Before a saccadic eye movement to a location in the visual periphery, human observers' foveal vision becomes more sensitive to the features defining the eye movement target, anticipating information that will soon be fixated in a retinotopic reference frame.

Blastocyst complementation of rat embryos with donor mouse embryonic stem cells was used to simultaneously produce multiple, donor-derived hematopoietic and stromal cells in the interspecies bone marrow that exhibited normal gene expression signatures, cell surface markers, and functional characteristics.

Active selfish genetic elements in infected cells aid virus adaptation by catalyzing the transfer of host genes to virus genomes.

A new experimental system of horizontal gene transfer demonstrates that host retrotransposons facilitate the transfer of host genes into poxviruses.

Extrachromosomal circular DNA will hold great promise in future biomedical research and clinical translational application.

Human blood derived macrophage polarisation can be classified by proxy of their metabolism, using advanced microscopy techniques generating single-cell parameters that are clustered and validated using machine learning classification models.

Nuclear phosphorylation differentially controls the activity of Hippo pathways effectors YAP and TAZ via distinct molecular mechanisms under physiological and tissue damage conditions.